Methyl (5-Benzoyl-1H-Benzo[D]Imidazol-2-Yl)Carbamate (5-苯甲酰基-1H-苯并[d]咪唑-2-基)氨基甲酸甲酯

CAS 31431-39-7 MFCD00057872

化学结构图

31431-39-7
SMILES: COC(=O)NC1NC2C=CC(=CC=2N=1)C(=O)C1C=CC=CC=1

化学属性

Mol. FormulaC16H13N3O3
Mol. Weight295
Melting Point288.5

别名和识别编码

Chemical NameMethyl (5-Benzoyl-1H-Benzo[D]Imidazol-2-Yl)Carbamate
CAS Number31431-39-7
Synonym (5-Benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester 2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester 5-Benzoyl-2-benzimidazolecarbamic acid methyl ester 5-Benzoyl-2-benzimidazolecarbamicacimethylester 5-苯甲酰-2-苯并咪唑胺甲酸甲酯 N-(5-苯甲酰-1H-苯并咪唑-2-基)氨基甲酸甲酯 甲苯咪唑 Bantenol Besantin Mebendazole Mebenvet Methyl 5-benzoyl benzimidazole-2-carbamate Methyl 5-benzoyl-2-benzimidazolecarbamate N-(Benzoyl-5, benzimidazolyl)-2, carbamate de methyle Noverme Ovitelmin Pantelmin Telmin Vermicidin Vermirax Vermox Verpanyl 甲苯达唑
MDL NumberMFCD00057872
PubChem Substance ID135727223
Beilstein Registry Number759809
EC Number250-635-4
Chemical Name Translation(5-苯甲酰基-1H-苯并[d]咪唑-2-基)氨基甲酸甲酯
Reaxys-RN759809
Merck Number5768
Wiswesser Line NotationT56 BM DNJ CMVO1 GVR
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分类

  • Alphabetic, Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antiparasitic / Antiprotozoal / Anthelminthic, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, M, MEA - MES, Neat Compounds, Spectrum of Activity
  • {SA} Analytical Standards, Analytical/Chromatography, Antibiotics, Chemical Structure, Chromatography, Clinical Standards, Others
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Antibiotics,
  • {SNA} Additional Drugs,
  • {SNA} Additional Drugs,

产品应用

  • Anthelmintic (Nematodes).

相关文献及参考

  • Al-Badr, A.A., et al.: Anal. Profiles Drug Subs., 16, 291 (1987)
  • Merck 14 ,5768

安全信息

WGK Germany3
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Hazard Codes Xn
RTECSEY8600000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P301+P312+P330
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 714 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 19,735,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : >40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3

TYPE OF TEST            :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1280 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,1207,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : >640 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported ot

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,1207,1990

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 270 nmol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   26,292,1995

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
REFERENCE :
   PCBRD2 Progress in Clinical and Biological Research.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1975- Volume(issue)/page/year:
   340E,225,1990

TYPE OF TEST            : Body fluid assay
TEST SYSTEM             : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 mg/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   38,4478,1978

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 10 mg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 31,

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 2 mg/L
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 31,505,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 78400 ug/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 31,505,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 78400 ug/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
   Comparee de Lyon.  (Lyons, France)  V.1-83, 1898-1981.
   Volume(issue)/page/year: 76,147,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 78400 ug/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 31,505,1976

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