(S)-Timolol Maleate (S)-马来酸噻吗洛尔
CAS 26921-17-5 MFCD00058356
化学结构图
SMILES: CC(C)(C)NC[C@@H](O)COC1=NSN=C1N1CCOCC1.OC(=O)/C=C\C(O)=O |&1:6|
化学属性
| Mol. Formula | C13H24N4O3S.C4H4O4 |
|---|---|
| Mol. Weight | 432.55 |
| Melting Point | 202-203 °C(lit.) |
别名和识别编码
| Chemical Name | (S)-Timolol Maleate |
|---|---|
| CAS Number | 26921-17-5 |
| Synonym | l-Timolol maleate (2S)-1-[(1,1-Dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]- Betime Timolol maleate Timoptic Timoptol (-)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-2-propanol maleate Timolol maleate salt (S)-Timolol hydrogen maleate MK 950 Timolol hydrogen maleate Timacor |
| PubChem Substance ID | 24277810 |
| EC Number | 248-111-5 |
| MDL Number | MFCD00058356 |
| Wiswesser Line Notation | T6N DOTJ A- DT5NSNJ EO1YQ1MX1&1&1 &QV1U1VQ |
| Chemical Name Translation | (S)-马来酸噻吗洛尔 |
| LabNetwork Molecule ID | LN01300127 |
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分类
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals,
- {SNA} Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Merck, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives, T
产品应用
- Antihypertensive; antiarrhythmic (class II); antianginal; antiglaucoma agent.
相关文献及参考
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安全信息
GHS Symbol
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- H302 Harmful if swallowed 吞食有害
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
- R22 Harmful if swallowed 吞咽有害
- S36 Wear suitable protective clothing 穿戴适当的防护服；
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 805 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,1204,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1137 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,1204,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 881 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,464,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Ocular SPECIES OBSERVED : Human - man DOSE/DURATION : 39 mg/kg/87W-I TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 143,1627,1983
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