Kasugamycin Hydrochloride 春雷霉素盐酸盐
CAS 19408-46-9 MFCD00058459
化学结构图
SMILES: Cl.C[C@H]1O[C@H](O[C@@H]2[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@H]2O)[C@@H](N)C[C@@H]1NC(=N)C(O)=O
化学属性
| Mol. Formula | C14H25N3O9· HCl |
|---|---|
| Mol. Weight | 415.82 |
别名和识别编码
| Chemical Name | Kasugamycin Hydrochloride |
|---|---|
| Synonym | Kasugamycin, monohydrochloride 春雷霉素盐酸盐一水合物 3-O-[2-Amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-D-arabino-hexopyranosyl]-D-chiro-inositol Kasugamycin hydrochloride Kasumin |
| MDL Number | MFCD00058459 |
| PubChem Substance ID | 24896238 |
| CAS Number | 19408-46-9 |
| Chemical Name Translation | 春雷霉素盐酸盐 |
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分类
- {SNA} A - K, Aminoglycosides, Analytical Standards, Analytical/Chromatography,
- {SNA} A - K, Aminoglycosides, Antibacterial, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, Antifungal, Antineoplastic and Immunosuppressive Antibiotics, Chemical Structure Class, Genetic Marker Selection, Interferes with Protein Synthesis, Mechanism of Action, Spectrum of Activity, 抗生素, 生化试剂
- A - K, Aminoglycosides, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics, Antibiotics A to Z,
相关文献及参考
- 1. Pallaiah Thammana and Charles R. Cantor, Studies on ribosome structure and interactions near the m26A m26A sequence Nucleic Acids Res. 5 , 805-824, (1978)
- 2. BS Schuwirth, JM Day, et al., Structural analysis of kasugamycin inhibition of translation. Nat. Struct. Mol. Biol. 13 , 879-886, (2006) 摘要
- Kojima, I., et al., The rpoZ gene, encoding the RNA polymerase omega subunit, is required for antibiotic production and morphological differentiation in Streptomyces kasugaensis . J. Bacteriol. 184 , 6417-23, (2002) 摘要
- Masukawa, H., et al., Inhibition by kasugamycin of protein synthesis in Piricularia oryzae . J. Antibiot. 21 , 73-4, (1968) 摘要
安全信息
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (10),66,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3850 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -,225,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20900 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (2),18,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -,225,1969
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