N-Ethyl-3-Hydroxy-2-Phenyl-N-(Pyridin-4-Ylmethyl)Propanamide N-乙基-3-羟基-2-苯基-N-(吡啶-4-基甲基)丙酰胺

CAS 1508-75-4 MFCD00058580

化学结构图

1508-75-4
SMILES: CCN(Cc1ccncc1)C(=O)C(CO)c1ccccc1

化学属性

Mol. FormulaC17H20N2O2
Mol. Weight284
TSCANo
Melting Point97-100
Solubility45% (w/v) aq 2-hydroxypropyl-β-cyclode?xtrin: soluble4.3 mg/mL ethanol: soluble5.6 mg/mL H2O: insoluble
Appearance solid

别名和识别编码

Chemical NameN-Ethyl-3-Hydroxy-2-Phenyl-N-(Pyridin-4-Ylmethyl)Propanamide
CAS Number1508-75-4
Synonym N-ethyl-N-(4-pyridylmethyl)tropamide n-ethyl-2-phenyl-n-(4-pyrid N-Ethyl-?-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide n-ethyl-alpha-(hydroxymethyl)-n-(4-pyridinylmethyl)-benzeneacetamid N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide, Ro 1-7683 Epitromina TROPICAMIDE Mydriacyl tropi N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamid Tropic acid-N-eth Hydracrylamide, N-ethyl-2-phenyl N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide Ro 1-7683 N-Ethyl-N-(g-picolyl)tropamide N-乙基-N-(4-吡啶甲基)-alpha-羟甲基-苯乙酰胺 N-ETHYL-3-HYDROXY-2-PHENYL-N-PYRIDIN-4-YLMETHYL-PROPIONAMIDE {} {} {u Mydrum Benzeneacetamide, N-ethyl-alpha-(hydroxymethy component of Paremyd N-​Ethyl-​2-​ph
MDL NumberMFCD00058580
PubChem Substance ID87577232
EC Number216-140-2
Merck Number9780
Chemical Name TranslationN-乙基-3-羟基-2-苯基-N-(吡啶-4-基甲基)丙酰胺
Reaxys-RN285563
Beilstein Registry Number285563
LabNetwork Molecule IDLN00873077
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分类

  • {SNA} Antagonists, Bioactive Small Molecules, Cell Signaling and Neuroscience, Cholinergics, Neuroscience, Neurotransmission, Neurotransmitters, T, 细胞生物学
  • {SNA} Antagonists, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cholinergics,
  • Heterocycles
  • Pharmaceuticals
  • {uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; 6RingOnly; 6ring; amide; alcohol; racemate; 1fragment
  • {SNA} Antagonists, Bioactive Small Molecule Alphabetical Index, Cholinergics, Neuroscience, Neurotransmission, Neurotransmitters, T, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Intermediates & Fine Chemicals,

产品应用

  • M4毒蕈碱型乙酰胆碱受体拮抗剂。

相关文献及参考

  • [2]. Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110(4): p. 1413-20.
  • ########
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
  • Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A Year: 1995 Keyword: organic compounds; enthaly of fusion; melting point; phase transition ISBN: 3-540-58854-X ISBN: 978-3-540-58854-2 Internet Resource: DOI:10.1007/b55145 RefComment: VIII, 588 pages.
  • [1]. Lazareno, S., N.J. Buckley, and F.F. Rober

安全信息

GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
WGK Germany3
Signal word
Hazard Codes Xn
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R42/43
RTECSCY1487860
Storage condition 储存温度2-8℃ 2-8°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 865 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,760,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 695 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,760,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 872 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,760,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 565 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1210 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,760,1990

其他信息

  • 眼科用药:托吡卡胺是一种抗胆碱药，常温下为白色结晶性粉末，无臭，在水中微溶，在乙醇、稀盐酸、稀硫酸和氯仿中易溶，能阻滞乙酰胆碱引起的虹膜括约肌及睫状肌兴奋作用。其0.5%溶液可引起瞳孔散大;1%溶液可引起睫状肌麻痹及瞳孔散大。临床上主要用于治疗滴眼散瞳和调节麻痹。 托吡卡胺是托品酸的合成衍生物。具有较低的解离常数，眼内通透性良好，组织扩散力强，可能是其起始迅速，维持时间短的原因。本品0.5%、1%溶液滴眼后20-30分钟内散瞳及调节麻痹作用达高峰。随后作用逐渐降低，调节麻痹（残余的）２～６小时。散瞳（残余的）约7小时。托吡卡胺是类似阿托品的药物，故可使闭角型青光眼眼压急剧升高，也可能激发未被诊断的闭角型青光眼。 托吡卡胺滴眼液的睫状肌调节麻痹作用强度与剂量密切相关，其0.25%、0.5%、0.75%和1%四种浓度均有调节麻痹作用。滴眼后，最大残余调节度数分别为0.25%3.17屈光度、1%1.30屈光度。残余调节度数能保持在2.0屈光度或以下者，0.75%和1%溶液可维持40分钟，0.5%约为15分钟。1%溶液一滴滴眼后隔5~25分钟再滴第二次，能获得更满意的睫状肌麻痹作用约20~30分钟。经2~6小时能阅读书报，调节功能于6小时内恢复至滴药前水平。
  • TCI Shanghai:托品酰胺 Tropicamide,>;99.0%(LC)(T)(1508-75-4)
  • 托吡卡胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 T1470 托品酰胺 Tropicamide 10G 2010元
  • 用途一:抗胆碱药，散瞳药。
  • MSDS 信息:N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide(1508-75-4).msds
  • color:white
  • MOL 文件:1508-75-4.mol
  • Sigma Aldrich:1508-75-4(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. T - Bioactive Small Molecules
  1. Medical Research Areas
  2. GPCR & G Protein
  3. mAChR  (毒蕈碱型乙酰胆碱受体)

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