H-Met-OH L-蛋氨酸

CAS 63-68-3 MFCD00063097

化学结构图

63-68-3
SMILES: CSCC[C@H](N)C(=O)O

化学属性

Mol. FormulaC5H11NO2S
Mol. Weight149.21
Density1.206
Melting Point284°C
TSCAYes
SolubilitySoluble in 1M HCl (50 mg/ml), and water (56.6 mg/ml at 25 °C). Insoluble in ethanol, acetone, and ether.
Appearance 为白色片状结晶或结晶性粉末， 特臭， 微甜。 mp280-282℃(分解)， 无旋光性， 对热及空气稳定， 对强酸不稳定， 可导致脱甲基作用。 溶于水(3.5%, 25℃), 稀酸和稀碱溶液， 极难溶于乙醇， 不溶于乙醚。 等电点5.74。 DL-蛋氨酸从醇中结成白色薄片状结晶或结晶性粉末，微甜，有特殊气味。无旋光性。 能溶于水、稀酸和稀碱类，微溶于95%的醇，不溶于醚。
Stability对光敏感
Boiling Point393.91 °C at 760 mmHg

别名和识别编码

Chemical NameH-Met-OH
CAS Number63-68-3
Alfabeta NameAMINOMETHYLTHIOBUTANOICACID S24(())----
MDL NumberMFCD00063097
Synonym L-Methionine {LY} L-Methionine {} {LY} L-Methionine {} {} {LY} L-Methionine {} {} {} {LY} L-Methionine {} {} {} {} {LY} L-Methionine {} {} {} {} {} {LY} L-Methionine {} {} {} {} {} {} {LY} L-Methionine {} {} {} {} {} {} {} {LY} L-Methionine {} {} {} {} {} {} {} {} {LY} L-Methionine {} {} {} {} {} {} {} {} {} {LY} L-Methionine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Methionine {} {} {} {} {} {} {} {} {} {} {} {LY} L-Methionine {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Methionine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Methionine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Methionine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Methionine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Methionine {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number200-562-9
Beilstein Registry Number1722294
PubChem Substance ID6137
Merck Number5975
Reaxys-RN1722294
Chemical Name TranslationL-蛋氨酸
InChIKeyFFEARJCKVFRZRR-BYPYZUCNSA-N
Wiswesser Line NotationQVYZ2S1 -L
LabNetwork Molecule IDLN00175833
InChIInChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
Canonical SMILESN[C@@H](CCSC)C(O)=O
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分类

  • {SNA} Allium cepa (Onion), Allium sativum (Garlic), Amino Acid Derivatives, Amino Acid Library, Amino Acids, Amino Acids & Vitamins, Amino Acids and Vitamins, Amino acids, Analytical/Chromatography, Bioactive Small Molecules, Biochemicals and Reagents, Biomolecular Mass Spectrometry,

产品应用

  • An essential amino acid

相关文献及参考

  • Benevenga, N.J., et al.: J. Agric. Food Chem., 22, 2 (1974),
  • Fleisher, L.D., et al.: Clin. Endocrinol. Metab., 3, 37 (1974),
  • Merck: 14,5975 Beilstein:4(2)938
  • Short: IV/20A
  • Short: IV/20C
  • Short: IV/20B
  • Short: III/10a
  • Merck: 14,5975
  • Meinnel, T., et al.: Biochimie, 75, 1061 (1993),

安全信息

Warnings IRRITANT
Signal word Warning
GHS Symbol
WGK Germany1
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R33 Danger of cumulative effects 有累积作用的危险
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P312+P330
  • P305+P351+P338
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSPD0457000
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Storage condition 2-8°C {LY} 2-8°C Store at RT. {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 36 gm/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Immunological Including Allergic - uncharacterized
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 48(6),20,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4328 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ABBIA4 Archives of Biochemistry and Biophysics.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.31-    1951-  Volume(issue)/page/year:
   58,253,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >9500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,682,1981

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 2 umol/L
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   696,15,1982

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 200 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,224,1981

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - guinea pig
DOSE/DURATION           : 500 mg/kg
REFERENCE :
   JCLBA3 Journal of Cell Biology.  (Rockefeller Univ. Press, 1230 York Ave.,
   New York, NY 10003) V.12-    1962-  Volume(issue)/page/year: 47,190a,1970

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 372,75,1996

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 2 umol/L
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   696,15,1982

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 500 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 14720 mg/kg
SEX/DURATION            : female 10-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   DTTIAF Deutsche Tieraerztliche Wochenschrift.  (Hanover, Fed. Rep. Ger.)
   V.1-77, 1893-1970.  Volume(issue)/page/year: 82,457,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 26100 mg/kg
SEX/DURATION            : female 10-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   DTTIAF Deutsche Tieraerztliche Wochenschrift.  (Hanover, Fed. Rep. Ger.)
   V.1-77, 1893-1970.  Volume(issue)/page/year: 82,457,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 35 gm/kg
SEX/DURATION            : female 2 week(s) pre-mating
                          female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 46,499,1992

其他信息

  • MOL 文件:63-68-3.mol
  • Alfa Ae
  • 含量分析:精确称取试样约300mg，移入具玻塞烧瓶中。加水100ml，磷酸氢二钾5g，磷酸二氢钾2g和碘化钾2g，充分混合至溶解。再加精确量取的0.1mol/L碘液50ml，塞紧烧瓶，
  • 上游原料:碳酸氢铵 --> 丙烯醛
  • 参考质量标准:FCC，1996 含量(以干基计) 98.5%～101.5% 重金属(以Pb计，GT-16-2试样1g) ≤10mg/kg 铅
  • 下游产品:(S)-(+)-2-氨基-4-(甲基硒)丁酸 --> L-亮氨酸 --> DL-蛋氨酸 --> [MET5]脑啡肽 --> N-乙酰-L-蛋氨酸
  • F:10-23
  • Acros Organics:L-蛋氨酸/L-甲硫氨酸 L-Methionine, 98+%(63-68-3)
  • 方法二:技术路线 工艺过程 脱水 按甘油、硫酸氢钾、硫酸钾以1:0.5:0.026的配料比投料。 先将投量的甘油1/7及全部应投的硫酸氢钾、硫酸钾投入反应罐内， 升温到190℃后开始滴加其余的甘油， 控制反应的温度180-220℃, 反应生成的丙烯醛气体， 经冷凝器收集在贮罐内，得丙烯醛粗品。 将粗品加10%NaHCO3溶液调至pH6, 进行分馏， 收集50-75℃馏分， 得丙烯醛粗品。加成 按丙烯醛、硫酸甲基异硫脲、氢氧化钠、醋酸铜、甲酸以1:2.45:3.8:0.01:0.024的比例配比投料。 环合 先将硫酸甲基异硫脲投入甲硫醇发生罐中， 滴加NaOH溶液， 并同时加热控制温度不超过95℃， 将生成的甲硫醇首先进入缓冲罐， 再进入盛有50%硫酸液的洗涤罐及另一级冲罐， 最后进入预先投入了丙烯醛、甲酸和醋酸铜的加成罐内， 加热搅拌， 保持反应温度在35-41℃。 当反应快接近终点时， 反应物呈淡黄色并混有絮状物， 并不时测定其相对密度， 当相对密度在1.066-1.074 (20℃) 时表明反应巳达终点。 得3-甲硫基丙醛。 按3-甲硫基丙醛、氰化钠、碳酸氨铵以1:0.52:1.75的配料比例投料。 分别将碳酸氢铵溶于其重量4倍的水和氰化钠溶于其重3倍的水后， 投入反应罐中， 在搅拌下缓缓滴加3-甲硫基丙
  • FEMA:3301
  • 用途二:氨基酸类药、营养增补剂。 用于肝硬变及脂肪肝。此外大量用作饲料添加剂， 以改善饲料质量， 提高天然蛋白质的利用率和促进动物的发育。 如DL-蛋氨酸可提高鸡的产蛋量， 使生猪体重增加， 奶牛多产奶等。 不良反应：肝昏迷忌用。
  • L-蛋氨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 62017434 L-甲硫氨基酸 25g 30元 2011/04/16 M0099 L-蛋氨酸 L-Methionine 25G 263元 2011/04/16 M0099 L-蛋氨酸 L-Methionine 500G 2040元
  • Sigma Aldrich:63-68-3(sigmaaldrich)
  • 含量分析:精确称取试样约300mg，移入具
  • 所属类别二:生物化学品: 氨基酸类: 中性氨基酸
  • 上游原料:氰化钠 --> Α-球蛋白 --> 碳酸氢铵 --> 丙烯醛 --> 醋酸铜 --> 甲硫醇,压力包装,约为22克。 --> L-蛋氨酸
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量（g/kg） 最大允许残留量（g/kg） L-蛋氨酸 食品 食品用香料 用于配制香精的各香料成分不得超过在GB 2760中的最大允许使用量和最大允许残留量
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量（g/kg） 最大允许残留量（g/kg） dl-蛋氨酸 食品 食品用香料 用于配制香精的各香料成分不得超过在GB 2760中的最大允许使用量和最大允许残留量
  • 比旋光度:23.25 ° (c=2, 6N HCl)
  • 海关编码:29304010

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  1. Application Areas 应用领域分类
  2. Drug Discovery 新药研发
  3. Pharmacopoeia 药典
  4. Pharmacopoeia A-Z - Pharmacopoeia
  1. Research Essentials 基础科研
  2. Core Bioreagents - Research Essentials
  3. Life Science Reagents for Cell Culture - Core Bioreagents
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  4. BioUltra - Amino Acids
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. M - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Libraries - Metabolomics
  4. Amino Acid Library - Metabolic Libraries
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Functional Foods - Nutrition Research
  4. Amino acids - Functional Foods
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Allium sativum (Garlic) - Phytochemicals by Plant (Food/Spice/Herb)
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Methionine - Amino Acid Derivatives
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Pathways - Metabolomics
  4. Metabolites and Cofactors on the Metabolic Pathways Chart - Metabolic Pathways
  5. Amino Acid - Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Food & Beverage Standards - Chromatography
  5. Nutraceuticals - Food & Beverage Standards
  6. Flavors and Fragrances - Nutraceuticals
  7. M-R - Flavors and Fragrances
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Amino Acids and Vitamins
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Amino Acids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Albumins and Transport Proteins
  4. Albumin
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals Found in Plants
  4. Alkaloid
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Culture
  4. Amino Acids and Vitamins
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Libraries
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Reagents and Supplements
  4. Amino Acids and Vitamins
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Libraries
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Culture
  4. Reagents and Supplements
  5. Amino Acids and Vitamins
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Pathways
  5. Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Nutrition Research
  4. Biochemicals Found in Plants
  5. Alkaloid
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Pathways
  6. Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)