Meprobamate Meprobamate

CAS 57-53-4 MFCD00063428

化学结构图

57-53-4
SMILES: CCCC(C)(COC(N)=O)COC(N)=O

化学属性

Mol. FormulaC9H18N2O4
Mol. Weight218.29
Flash Point11 °C
Appearance 白色流动性粉末,有硫化物特殊气味。可溶于水。

别名和识别编码

Chemical NameCIV (200 mg)
CAS Number57-53-4
Synonym ######## 2,2-Di(carbamoyloxymethyl)pentane 2-METHYL-2-PROPYL-1, 2-METHYL-2-PROPYLPROPANE-1,3-DIOL DICARBAMATE 2-Methyl-2-n-propyl-1,3-propanediol dicarbamate 2-Methyl-2-propylpropane-1,3-diol dicarbamate; 2-Methyl-2-propyltrimethylene carbamate 2-methyl-2-n-propyl-1,3-propanedioldicarbamate 2-methyl-2-propyltrimethylenecarbamate 2-metil-2-n-propil-1,3-propanedioldicarbamato 3pbamate Amepromat Amosene Anathylmon Anatimon Andaksin Andaxin Ansiatan Arcoba Artolon Atraxin Ayermate Bamo 400 Biobamat Brobamate Calmiren Canquil-400 Cirpon Cyrpon Dapaz Dic
MDL NumberMFCD00063428
EC Number200-337-5
PubChem Substance ID4064
Chemical Name TranslationMeprobamate
Wiswesser Line NotationZVO1X3&1&1OVZ
Beilstein Registry Number1788882
InChIInChI=1S/C9H18N2O4/c1-3-4-9(2,5-14-7(10)12)6-15-8(11)13/h3-6H2,1-2H3,(H2,10,12)(H2,11,13)
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分类

  • Aliphatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,
  • {uni_hamburg} no charge; carbamate; 1fragment
  • {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, Chemical Structure, Chromatography, Drugs of Abuse, Forensic and Veterinary Standards, M, MEA - MES, Others
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chemical Structure, Chromatography, Drugs of Abuse, Forensic and Veterinary Standards, M, MEA - MES, Others

产品应用

  • An anxiolytic.

相关文献及参考

  • Summerfield, S., et al.: J. Pharmacol. Exp. Ther., 322, 205 (2007),
  • Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008),
  • Cone, E., et al.: J. Anal. Toxicol., 33, 1 (2009),
  • Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A Year: 1995 Keyword: organic compounds; enthaly of fusion; melting point; phase transition ISBN: 3-540-58854-X ISBN: 978-3-540-58854-2 Internet Resource: DOI:10.1007/b55145 RefComment: VIII, 588 pages.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

GHS Symbol
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P312
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P330 Rinse mouth. 漱口
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSTZ0175000
Hazard Codes Xn Xn,T,F
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R11 Highly flammable 非常易燃
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
Storage condition 2-8°C
UN Number UN 1230 3/PG 2
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S7 Keep container tightly closed 保存在严格密闭容器中;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
Restrict {} 精神药品 精麻类化学品
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 760 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   207,361,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 384 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Vascular - regional or general arteriolar constriction
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   NOMDA6 Northwest Medicine.  (Seattle, WA)  V.1-73, 1903-73.  Discontinued.
   Volume(issue)/page/year: 56,321,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 26,109,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   OSMJAT Ohio State Medical Journal.  (Ohio State Medical Assoc., 600 S. High
   St., Suite 500, Columbus, OH 43215)  V.1-    1905- Volume(issue)/page/year:
   52,1304,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 26667 ug/kg
REFERENCE :
   PISCAD Proceedings of the Indian Science Congress.  (Indian Science Congress
   Assoc., 14, Dr. Biresh Guha St., Calcutta, 700017, India)  1st- 1914- 
   Volume(issue)/page/year: 59(Pt 3),547,1972

{h

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 750 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   KAIZAN Kaibogaku Zasshi.  Journal of Anatomy.  (Nippon Kaibo Gakkai, c/o
   Tokyo Daigaku Igakubu, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan)  V.1- 1928-
    Volume(issue)/page/year: 38,258,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5500 mg/kg
SEX/DURATION

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 500 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   KAIZAN Kaibogaku Zasshi.  Journal of Anatomy.  (Nippon Kaibo Gakkai, c/o
   Tokyo Daigaku Igakubu, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan)  V.1- 1928-
    Volume(issue)/page/year: 38,258,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6400 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
                          lactating female 28 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 202,832,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED

其他信息

  • 方法二:2-甲基戊醛与甲醛进行醛醇缩合反应得到2-甲基-2-丙基丙二醇,然后与光气及氨反应,或与氰酸钠及盐酸反应制得甲丙氨酯。
  • 上游原料:丙二醇 --> 氰酸钠 --> DL-蛋氨酸 --> 3-羟基丁醛 --> 2-甲基戊醛
  • MOL 文件:57-53-4.mol
  • Sigma Aldrich:57-53-4(sigmaaldrich)
  • 用途一:本品是饲料营养强化剂,适合于反刍动物,具有在瘤胃中降解的保护作用,用于奶牛饲料中可提高牛奶的产量和牛奶的蛋白质含量,延长产乳期。
  • MSDS 信息:2-Methyl-2-propylpropane-1,3-diol dicarbamate(57-53-4).msds
  • 方法一:由DL-蛋氨酸为原料生产而得。
  • 用途二:弱安定药。用于治疗神经官能症的焦滤紧张失眠。

系列性分类


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