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• 试剂商城
• 直接询价

分类

• {SNA} Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Biochemicals and Reagents, Genetic Marker Selection, Interferes with Protein Synthesis, L - Z, Mechanism of Action, Spectrum of Activity
• {SNA} Antibacterial, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Genetic Marker Selection, Interferes with Protein Synthesis, L - Z, Mechanism of Action, Spectrum of Activity, 抗生素, 生化试剂
• {SNA} Antibacterial,

产品应用

• The aminonucleoside portion of the antibiotic puromycin.

相关文献及参考

• [2]. Wada T, et al. Prevents podocyte apoptosis induced by puromycin aminonucleoside: role of p53 and Bcl-2-related family proteins. J Am Soc Nephrol. 2005 Sep;16(9):2615-25.
• [3]. Gong W, et al. Estrogen-related receptor-α mediates puromycin aminonucleoside-induced mesangial cell apoptosis and inflammatory injury. Am J Physiol Renal Physiol. 2019 May 1;316(5):F906-F913.
• [4]. Xia L, et al. Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleosidenephrotoxicity. Am J Physiol Renal Physiol. 2009 Jun;296(6):F1307-13.
• [5]. Kawakami H, et al. Dynamics of absolute amount of nephrin in a single podocyte in puromycin aminonucleoside nephrosis rats calculated by quantitative glomerular proteomics approach with selected reaction monitoring mode. Nephrol Dial Transplant. 2012 Apr;
• [6]. Nosaka K, et al. An adenosine deaminase inhibitor prevents puromycin aminonucleoside nephrotoxicity. Free Radic Biol M

安全信息

GHS Symbol

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Lung
DOSE/DURATION           : 6 mg/L
REFERENCE :
   JCLLAX Journal of Cellular Physiology.  (Alan R. Liss, Inc., 41 E. 11th St.,
   New York, NY 10003) V.67-    1966-  Volume(issue)/page/year: 81,71,1973

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 83 mg/kg
REFERENCE :
   JCLBA3 Journal of Cell Biology.  (Rockefeller Univ. Press, 1230 York Ave.,
   New York, NY 10003) V.12-    1962-  Volume(issue)/page/year: 30,13,1966

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lung
DOSE/DURATION           : 6 mg/L
REFERENCE :
   JCLLAX Journal of Cellular Physiology.  (Alan R. Liss, Inc., 41 E. 11th St.,
   New York, NY 10003) V.67-    1966-  Volume(issue)/page/year: 81,71,1973

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Lung
DOSE/DURATION           : 100 mg/L
REFERENCE :
   JCLLAX Journal of Cellular Physiology.  (Alan R. Liss, Inc., 41 E. 11th St.,
   New York, NY 10003) V.67-    1966-  Volume(issue)/page/year: 81,71,1973

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 83 mg/kg
REFERENCE :
   JCLBA3 Journal of Cell Biology.  (Rockefeller Univ. Press, 1230 York Ave.,
   New York, NY 10003) V.12-    1962-  Volume(issue)/page/year: 30,13,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 105 ug/kg
SEX/DURATION            : female 5-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 195,1209,1962

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 45 mg/kg
SEX/DURATION            : female 8-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   NPRNAY Nephron.  (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003)
   V.1-    1964-  Volume(issue)/page/year: 3,344,1966

其他信息

• Puromycin Aminonucleoside (3'-Amino-3'-deoxy-N6,N6-dimethyladenosine) is the aminonucleoside portion of the antibiotic puromycin. It is a puromycin analog which does not inhibit protein synthesis or induce apoptosis. Used in the study of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats. The excretion of sodium and NOx metabolites in rats with puromycin aminonucleoside-induced nephrotic syndrome has been studied. Used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability