4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide 4-氨基-N-(6-甲氧基嘧啶-4-基)苯磺酰胺

CAS 1220-83-3 MFCD00063466

化学结构图

1220-83-3
SMILES: COc1cc(NS(=O)(=O)c2ccc(N)cc2)ncn1

化学属性

Mol. FormulaC11H12N4O3S
Mol. Weight280.30
Melting Point203-206°C
Appearance 白色或类白色结晶性粉末,无臭,无味。熔点204-206℃。极微溶于水和乙醇,易溶于稀酸、稀碱液。遇光易被氧化而渐变暗。

别名和识别编码

Chemical Name4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide
CAS Number1220-83-3
Alfabeta NameAMINOMETHOXYPYRIMIDINYLBENZENESULFONAMIDE N464()-------
MDL NumberMFCD00063466
Synonym Sulfamonomethoxine {TRC} ######## 4-AMINO-N-[6-METHOXY-4-PYRIMIDINYL]BENZENESULFONAMIDE 4-Amino-N-(6-methoxy-4-pyrimidinyl)benzenesulfonamide 4-Amino-N-(6-methoxy-pyrimidin-4-yl)-benzenesulfonamide AKOS B014359 Benzenesulfonamide, 4-amino-N-(6-methoxy-4-pyrimidinyl)- DJ-1550 ICI 32525 N-(6-甲氧基-4-嘧啶基)-4-氨基苯磺酰胺 Ro 4-3476 SULAMONOMETHOXINE SULFAMONOMETHOXINE Sulfamomomethoxine(sodium) Sulfamomonethoxine Sulfamonomethoxin daimeton dj-1550 ici32525 ro4-3476 如磺胺间甲氧嘧啶 泰灭净 磺胺六甲氧嘧啶 磺胺间甲氧嘧啶,
PubChem Substance ID87577958
Beilstein Registry Number621128
Chemical Name Translation4-氨基-N-(6-甲氧基嘧啶-4-基)苯磺酰胺
Reaxys-RN621128
Wiswesser Line NotationT6N CNJ DO1 FMSWR DZ
LabNetwork Molecule IDLN00158705
InChIInChI=1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15)
Canonical SMILESO=S(C1=CC=C(N)C=C1)(NC2=NC=NC(OC)=C2)=O
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分类

  • {SNA} Additional Standards, Analytical Standards, Antibiotics Standards, Bacteriostatic, Chemical Structure, Chromatography, Clinical Standards, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds, Pharmaceuticals, Illicit Drugs & Alcohol, Principle, Sulfonamides, 分析/色谱
  • Inhibitor
  • {SNA} Analytical Standards, Analytical/Chromatography, Antibiotics, Bacteriostatic, Chemical Structure, Chromatography, Clinical Standards, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds, Principle,
  • {SNA} Antibacterial,

产品应用

  • Protein binding. Inhibitor of enzyme. Sulfamonomethoxine and Trimethoprim

相关文献及参考

  • Bridges, et al.: Biochem. J., et al.: 96, 829 (1965),

安全信息

Warnings IRRITANT
WGK Germany2
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352
  • P302+P352+P333+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P332+P313
  • P333+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSWP0550000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xi
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Storage condition 2-8°C {TCI} 0-10 0-10°C 0-6°C
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4680 mg/

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - food intake (animal)
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 9,133,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - irritability
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Ya

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1010 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,391,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >7 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - irritability
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 9

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3 gm/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 13,7,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3 gm/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 13,7,1973

其他信息

  • 磺胺间甲氧嘧啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 S0592 磺胺间甲氧嘧啶 Sulfamonomethoxine 5G 506元 2014/06/02 S0592 磺胺间甲氧嘧啶 Sulfamonomethoxine 25G 1290元
  • 用途一:磺胺类药,用于溶血性链球菌、肺炎球菌及脑膜炎球菌等感染
  • 上游原料:丙二酸二乙酯 --> 三氯乙烯 --> 丙二酸二丁酯
  • 参考质量标准:参见《中国兽药典》1990年版 含量(干基)/% ≥99.0 氯化物(CI - )/% ≤0.01 干燥失重/% ≤0.5 灼烧残渣/% ≤0.1 重金属/% ≤0.002
  • 方法一:由丙二酸二丁酯经环合、缩合、醚化、酸化等步骤制得。
  • 用途二:作为广谱抗菌剂,对溶血性链球菌、肺炎球菌、大肠杆菌均有效。主要用于治疗尿路感染、呼吸道感染,对动物支原体、工形体和球虫病等也有杀灭作用。
  • Sigma Aldrich:1220-83-3(sigmaaldrich)
  • MOL 文件:1220-83-3.mol

系列性分类


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