• S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
• S24 Avoid contact with skin 避免皮肤接触；
• S37 Wear suitable gloves 戴适当手套；
• S36 Wear suitable protective clothing 穿戴适当的防护服；

• R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
• R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
• R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1600 ug/kg/3W-I
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), diffuse
   Blood - agranulocytosis
REFERENCE :
   ANZJB8 Australian and New Zealand Journal of Medicine.  (Modern Medicine of
   Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia)
   V.1-    1971-  Volume(issue)/page/year: 16,72,1986

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 185 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 49,121,1

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 11900 ug/kg/18W-I
TOXIC EFFECTS :
   Biochemical - Metabolism (Intermediary) - other
REFERENCE :
   JRHUA9 Journal of Rheumatology.  (920 Yonge St., Suite 608, Toronto, Ont.,
   Canada)  V.1-    1974-  Volume(issue)/page/year: 13,224,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VTPHAK Veterinary Pathology.  (Waverly Press, Inc., POB 64025, Baltimore, MD
   21264)  V.8-    1971-  Volume(issue)/page/year: 15(Suppl 5),1,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 257 mg/kg
SEX/DURATION            : female 6-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   VTPHAK Veterinary Pathology.  (Waverly Press, Inc., POB 64025, Baltimore, MD
   21264)  V.8-    1971-  Volume(issue)/page/year: 15(Suppl 5),97,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 900 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   VTPHAK Veterinary Pathology.  (Waverly Press, Inc., POB 64025, Baltimore, MD
   21264)  V.8-    1971-  Volume(issue)/page/year: 15(Suppl 5),89,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 75 mg/kg
SEX/DURATION            : female 13-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 214,250,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE

TYPE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE