(S)-4-benzyloxazolidin-2-one (S)-4-benzyloxazolidin-2-one

CAS 90719-32-7 MFCD00064496

化学结构图

90719-32-7
SMILES: O=C1NC(Cc2ccccc2)CO1

化学属性

Mol. FormulaC10H11NO2
Mol. Weight177.20
Melting Point86-88°C
TSCANo
Appearance 白色或类白色粉末。熔点87-89℃ ，比旋光度 ; -62 º (C=1, CHCl3)，折射率 ; -14.5 ° (C=5, MeOH)
Density1.0
Stability易吸潮
Boiling Point398.8°C at 760 mmHg

别名和识别编码

Chemical Name(S)-4-benzyloxazolidin-2-one
MDL NumberMFCD00064496
PubChem Substance ID736225
Beilstein Registry Number3649667
CAS Number90719-32-7
Synonym (S)-4-Benzyl-2-oxazolidone {LY} (S)-4-Benzyl-2-oxazolidone {} {LY} (S)-4-Benzyl-2-oxazolidone {} {} {LY} (S)-4-Benzyl-2-oxazolidone {} {} {} {LY} (S)-4-Benzyl-2-oxazolidone {} {} {} {} {LY} (S)-4-Benzyl-2-oxazolidone {} {} {} {} {} {LY} (S)-4-Benzyl-2-oxazolidone {} {} {} {} {} {} {LY} (S)-4-Benzyl-2-oxazolidone {} {} {} {} {} {} {} {LY} (S)-4-Benzyl-2-oxazolidone {} {} {} {} {} {} {} {} {LY} (S)-4-Benzyl-2-oxazolidone {} {} {} {} {} {} {} {} {} {LY} (S)-4-Benzyl-2-oxazolidone {} {} {} {} {} {} {} {} {} {} {LY} (S)-4-Benzyl-2-oxazolidone {} {} {} {} {} {} {} {} {} {} {} {LY} (S)-4-Benzyl-2-oxazolidone {} {} {} {} {} {} {} {} {} {} {} {} {LY} (S)-4-Benzyl-2-oxazolidone {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} (S)-4-Benzyl-2-oxazolidone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} (S)-4-Benzyl-2-oxazolidone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} (S)-4-Benzyl-2-oxazolidone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} (S)-4-Benzyl-2-oxazolido
Reaxys-RN3649667
Chemical Name Translation(S)-4-benzyloxazolidin-2-one
LabNetwork Molecule IDLN00219951
InChIInChI=1S/C10H11NO2/c12-10-11-9(7-13-10)6-8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,11,12)/t9-/m0/s1
Canonical SMILESO=C1OC[C@H](CC2=CC=CC=C2)N1
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分类

  • {SNA} Asymmetric Synthesis, Chemical Synthesis, Chiral Auxiliaries, Oxazolidinone Derivatives

产品应用

  • 手性试剂，用于合成(S)-equol.，也用于非对称合成(3R)- 和 (3S)-piperazic acid及非对称烷化。

相关文献及参考

  • Evans chiral auxiliary; compare (4S)-(-)-Isopropyl-2-oxazolidinone, A14029.
  • A simplified method of acylation of the oxazolidinone, avoiding the need for rigorously anhydrous conditions, has been reported using acyl chlorides, anhydrides or pivaloyl mixed anhydrides as the acylating agents catalyzed by DMAP: Synthesis, 1283 (1996).
  • For details of use in enantioselective aldol condensation, see: Org. Synth. Coll., 8, 339 (1993):
  • See also (4S)-(-)-Isopropyl-2-oxazolidinone, A14029.

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 2-8°C {LY} 2-8°C Hygroscopic Store at room temperature {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Signal word Warning
Hazard statements
  • H316 Causes mild skin irritation 会轻微的刺激皮肤
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
GHS Symbol
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Hazard Codes Xi

其他信息

  • Sigma Aldrich:90719-32-7(sigmaaldrich)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Inorganic Bases - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Auxiliaries - Asymmetric Synthesis
  4. Oxazolidinone Derivatives - Chiral Auxiliaries
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Isoxazoles 异恶唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Oxazoles 恶唑
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chiral Auxiliaries
  4. Ephedrine Derivatives

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