rel-(2R,3S)-2,3-Dimercaptobutanedioic acid 内消旋-2,3-二巯基丁二酸

CAS 304-55-2 MFCD00064799

化学结构图

304-55-2
SMILES: O=C(O)[C@H](S)[C@H](S)C(=O)O

化学属性

Mol. FormulaC4H6O4S2
Mol. Weight182.22
Density1.617
Melting Point196-198°C
TSCAYes
Appearance 白色结晶性粉末。熔点196-198℃(分解)。易溶于碱溶液,微溶于甲醇,不溶于水。具有巯基化合物的特臭,在空气中逐渐氧化。
Solubility不溶于水,易溶于碱性溶液,微溶于甲醇。
Boiling Point267.57°C at 760 mmHg

别名和识别编码

Chemical Namerel-(2R,3S)-2,3-Dimercaptobutanedioic acid
CAS Number304-55-2
EC Number206-155-2
Beilstein Registry Number1725150
MDL NumberMFCD00064799
Synonym Succimer {LY} Succimer {} {LY} Succimer {} {} {LY} Succimer {} {} {} {LY} Succimer {} {} {} {} {LY} Succimer {} {} {} {} {} {LY} Succimer {} {} {} {} {} {} {LY} Succimer {} {} {} {} {} {} {} {LY} Succimer {} {} {} {} {} {} {} {} {LY} Succimer {} {} {} {} {} {} {} {} {} {LY} Succimer {} {} {} {} {} {} {} {} {} {} {LY} Succimer {} {} {} {} {} {} {} {} {} {} {} {LY} Succimer {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succimer {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succimer {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succimer {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succimer {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succimer {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succimer {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Merck Number14,8865
PubChem Substance ID87568194
Reaxys-RN1725150
Chemical Name Translation内消旋-2,3-二巯基丁二酸
Wiswesser Line NotationSHYVQYVQSH
LabNetwork Molecule IDLN01289148
InChIInChI=1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+
Canonical SMILESO=C(O)[C@@H](S)[C@@H](S)C(O)=O
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分类

  • {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfur Compounds, Thiols/Mercaptans

产品应用

  • 重金属解毒药。在用EDTA中镉滴定锌的过程中,作为选择性的掩蔽剂。

相关文献及参考

  • Merck: 14,8865 Beilstein: 3,III,1033
  • Merck: 14,8865
  • Water soluble chelating agent.

安全信息

Signal word Warning
GHS Symbol
WGK Germany2
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSWM7650000
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
Storage condition -20°C {LY} -20°C {} {LY} -20°C {} {} {LY} -20°C {} {} {} {LY} -20°C {} {} {} {} {LY} -20°C {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2700 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - hair
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 131,283,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5011 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CRTXB2 CRC Critical Reviews in Toxicology.  (CRC Press, Inc., 2000 Corporate
   Blvd., NW, Boca Raton, FL 33431)  V.1-    1971- Volume(issue)/page/year:
   20,83,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1725 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - hair
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 131,283,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD691-490

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 17600 mg/kg
SEX/DURATION            : female 14-21 day(s) after conception
                          lactating female 14 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - physical
REFERENCE :
   LIFSAK Life Sciences.  (Pergamon Press Inc., Maxwell House, Fairview Park,
   Elmsford, NY 10523) V.1-8, 1962-69; V.14-    1974- Volume(issue)/page/year:
   47,1745,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 30,181,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 30,181,1990

TYPE OF TEST            : TDLo

其他信息

  • 2,3-二巯基丁二酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D1722 内消旋-2,3-二巯基丁二酸 meso-2,3-Dimercaptosuccinic Acid 25G 2900元 2014/06/02 D1722 内消旋-2,3-二巯基丁二酸 meso-2,3-Dimercaptosuccinic Acid 5G 995元 2010/06/21 226670250 2,3-二巯基丁二酸 meso-2,3-Dimercaptosuccinic acid 98% 25 GR 3087元
  • 用途二:重金属解毒药。在用EDTA中镉滴定锌的过程中,作为选择性的掩蔽剂。
  • 用途一:该品是解毒药二巯基丁二酸钠的中间体。
  • Sigma Aldrich:304-55-2(sigmaaldrich)
  • 方法一:由二溴丁二酸经消除、加成、水解而得。
  • 图谱信息:2,3-二巯基丁二酸(304-55-2)红外图谱(IR2) 2,3-二巯基丁二酸(304-55-2)红外图谱(IR1) 2,3-二巯基丁二酸(304-55-2)质谱(MS)
  • MOL 文件:304-55-2.mol
  • F:10-23
  • Alfa Aesar:间-2,3-二巯基丁二酸,97% meso-2,3-Dimercaptosuccinic acid, 97%(304-55-2)
  • Acros Organics:meso-2,3-二巯基丁二酸 meso-2,3-Dimercaptosuccinic acid, 98%(304-55-2)
  • 上游原料:2,3-二溴丁二酸
  • TCI Shanghai:内消旋-2,3-二巯基丁二酸 meso-2,3-Dimercaptosuccinic Acid,>;98.0%(T)(304-55-2)

系列性分类