Diphenyl(4-Piperidinyl)Methanol 二苯基(4-哌啶基)甲醇

CAS 115-46-8 MFCD00066980

化学结构图

115-46-8
SMILES: OC(c1ccccc1)(c1ccccc1)C1CCNCC1

化学属性

Mol. FormulaC18H21NO
Mol. Weight267
Density1.422
Melting Point160-163
SolubilityDMSO 53 mg/mL Water 2 mg/mL Ethanol 53 mg/mL

别名和识别编码

Chemical NameDiphenyl(4-Piperidinyl)Methanol
CAS Number115-46-8
Synonym ######## 2,2-DIPHENYL-4-PIPERIDONOMETHANOL 4-(ALPHA,ALPHA DIPHENYL) PIPERIDINE METHANOL 4-Piperidinemethanol, alpha,alpha-diphenyl- ALPHA,ALPHA-DIPHENYL-4-PIPERIDINEMETHANOL ALPHA-(4-PIPERIDYL)BENZHYDROL AZACYCLONAL AZACYCLONOL Ataractan Azacyklonol DIPHENYL-4-PIPERIDINEMETHANOL Diphenyl-4-piperidylmethanol Frenoton Frenquel MER 17 TIMTEC-BB SBB003057 alpha,alpha-二苯基-4-哌啶甲醇 gamma-Pipradol; Azacyclonol gamma-pipradol α-(4-Piperidyl)benzhydrol 二苯基哌啶4-甲醇 氮杂环醇 氮杂环醇(α,α-二苯基-4-哌啶甲醇) 氮杂环醇, 阿杂环醇 阿扎环醇
EC Number204-092-5
Beilstein Registry Number230221
MDL NumberMFCD00066980
Reaxys-RN230221
PubChem Substance ID87575454
Chemical Name Translation二苯基(4-哌啶基)甲醇
LabNetwork Molecule IDLN00225302
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • ?-(4-Piperidyl)benzhydrol is a key intermediate in the synthesis of Fexofenadine (F322490).

相关文献及参考

  • Berthon, B., et al.: Biochem. Pharmcol., 47, 789 (1994),
  • Di Giacomo, B., et al.: Farmco, 54, 600 (1999),
  • Leues, R., et al.: Pharmacol. Ther., 66, 413 (1999),

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P350
  • P302+P352
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard Codes Xi
RTECSTN0470000
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Storage condition 储存温度-20°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSCBAY Psychopharmacology Service Center, Bulletin.  (Bethesda, MD)  V.1-3,
   1961-65.  For publisher information, see PSYBB9.  Volume(issue)/page/year:
   2,17,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 220 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSCBAY Psychopharmacology Service Center, Bulletin.  (Bethesda, MD)  V.1-3,
   1961-65.  For publisher information, see PSYBB9.  Volume(issue)/page/year:
   2,17,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSCBAY Psychopharmacology Service Center, Bulletin.  (Bethesda, MD)  V.1-3,
   1961-65.  For publisher information, see PSYBB9.  Volume(issue)/page/year:
   2,17,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 177 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSCBAY Psychopharmacology Service Center, Bulletin.  (Bethesda, MD)  V.1-3,
   1961-65.  For publisher information, see PSYBB9.  Volume(issue)/page/year:
   2,17,1963

其他信息

  • 下游产品:特非那定
  • 用途一:是药物盐酸非索非那定中间体
  • alpha,alpha-二苯基-4-哌啶甲醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 P1369 α-(4-哌啶基)二苯甲醇 alpha-(4-Piperidyl)benzhydrol 25G 810元 2010/06/21 232520050 alpha,alpha-二苯基-4-哌啶甲醇 alpha,alpha-Diphenyl-4-piperidinomethanol 98+% 5 GR 328元 2010/06/21 232520250 alpha,alpha-二苯基-4-哌啶甲醇 alpha,alpha-Diphenyl-4-piperidinomethanol 98+% 25 GR 918元
  • MSDS 信息:alpha,alpha-Diphenyl-4-piperidinomethanol(115-46-8).msds
  • MOL 文件:115-46-8.mol
  • 图谱信息:alpha,alpha-二苯基-4-哌啶甲醇(115-46-8)质谱(MS)
  • TCI Shanghai:α-(4-哌啶基)二苯基甲醇 alpha-(4-Piperidyl)benzhydrol,>;99.0%(GC)(115-46-8)
  • 海关编码:29333999
  • Acros Organics:二苯基哌啶4-甲醇 alpha,alpha-Diphenyl-4-piperidinomethanol, 98+%(115-46-8)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Homopiperidines 同哌啶
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperidines 哌啶

相关产品推荐