L-Hyoscyamine 莨菪碱

CAS 101-31-5 MFCD00067306

化学结构图

101-31-5
SMILES: CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)[C@H](CO)c1ccccc1)C2

化学属性

Mol. FormulaC17H23NO3
Mol. Weight289.37
Appearance 白色结晶性粉末，无臭，苦辣味。易消旋，水溶液呈碱性。Mp108.5℃，比旋光度[α] D 20 powder -21°(乙醇)。本品极易溶于乙醇和稀酸，易溶于氯仿(1：1)，可溶于水(1：280)、乙醚(1：69)和苯(1：159)。
Melting Point108.5 °C
Boiling Point429.804 °C at 760 mmHg

别名和识别编码

Chemical NameL-Hyoscyamine
MDL NumberMFCD00067306
CAS Number101-31-5
Synonym L-Hyoscyamine {LY} L-Hyoscyamine {} {LY} L-Hyoscyamine {} {} {LY} L-Hyoscyamine {} {} {} {LY} L-Hyoscyamine {} {} {} {} {LY} L-Hyoscyamine {} {} {} {} {} {LY} L-Hyoscyamine {} {} {} {} {} {} {LY} L-Hyoscyamine {} {} {} {} {} {} {} {LY} L-Hyoscyamine {} {} {} {} {} {} {} {} {LY} L-Hyoscyamine {} {} {} {} {} {} {} {} {} {LY} L-Hyoscyamine {} {} {} {} {} {} {} {} {} {} {LY} L-Hyoscyamine {} {} {} {} {} {} {} {} {} {} {} {LY} L-Hyoscyamine {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Hyoscyamine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Hyoscyamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Hyoscyamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Hyoscyamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Hyoscyamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
EC Number202-933-0
Reaxys-RN91259
Merck Number4858
Beilstein Registry Number91259
PubChem Substance ID154417
Chemical Name Translation莨菪碱
Wiswesser Line NotationT56 A ANTJ A1 GOVYR&1Q -L
LabNetwork Molecule IDLN00365394
InChIInChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15?,16-/m1/s1
Canonical SMILESCN1[C@@H]2C[C@@H](OC([C@@H](C3=CC=CC=C3)CO)=O)C[C@H]1CC2
信息真实价格透明    资金保障    专业采购外包团队在线服务   
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分类

  • {SNA} Antagonists, Cell Biology, Cell Signaling and Neuroscience, Cholinergics, Neuroscience, Neurotransmission, Neurotransmitters
  • {Chemicalbook} 生物化学品: 生化试剂: 生物碱

相关文献及参考

  • [2]. Harald John, et al. Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine. Drug Test Anal. Mar-Apr 2012;4(3-4):194-8.
  • [1]. Lars Göran Axelsson, et al. Regulatory role of 5-HT and muscarinic receptor antagonists on the migrating myoelectric complex in rats. Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8.
  • [1]. Lars Göran Axelsson, et al. Regulatory role of 5-HT and muscarinic receptor antagonists on the migrating myoelectric complex in rats. Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8.
  • [2]. Harald John, et al. Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine. Drug Test Anal. Mar-Apr 2012;4(3-4):194-8.

安全信息

RTECSNH0875000
WGK Germany3
Safety Statements
  • S24 Avoid contact with skin 避免皮肤接触；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Hazard Codes 6.1 T+
Risk Statements
  • R26/28 Very toxic by inhalation and if swallowed 吸入及吞食都有剧毒
UN Number 1544 UN 1544 6.1/PG 2
Signal word Danger
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310+P330
  • P304+P340+P310
  • P307+P311
  • P308+P311
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H300+H330
Packing GroupII
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Hazard Class6.1
GHS Symbol 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1471 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M.,
   Springfield, IL, C.C. Thomas, 1970  Volume(issue)/page/year: 2,73,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 95 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 24,138,1965

其他信息

  • Sigma Aldrich:101-31-5(sigmaaldrich)
  • 下游产品:硫酸阿托品
  • TCI Shanghai:(-)-莨菪碱 (-)-Hyoscyamine,>;99.0%(T)(101-31-5)
  • 用途一:生化研究，抗胆碱药及检测金的试剂。
  • MOL 文件:101-31-5.mol
  • color:white
  • 上游原料:颠茄浸膏
  • 方法一:颠茄浸膏经提取精制而得。
  • L-天仙子胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 H0450 (-)-莨菪碱 (-)-Hyoscyamine 5G 1020元 2014/06/02 H0450 (-)-莨菪碱 (-)-Hyoscyamine 25G 3010元
  • 参考质量标准:mp105-107℃，比旋光度-19°-21°，灼烧残渣≤0.1%。
  • 图谱信息:L-天仙子胺(101-31-5)核磁图( 13 CNMR) L-天仙子胺(101-31-5)质谱(MS) L-天仙子胺(101-31-5)Raman光谱 L-天仙子胺(101-31-5)红外图谱(IR1) L-天仙子胺(101-31-5)核磁图( 1 HNMR)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Cholinergics - Neurotransmitters
  8. Antagonists - Cholinergics
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Alkaloids
  1. Medical Research Areas
  2. GPCR & G Protein
  3. mAChR  (毒蕈碱型乙酰胆碱受体)

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