Ethyl 4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-Carboxylate 4-甲基-2-(4-(三氟甲基)苯基)噻唑-5-羧酸乙酯

CAS 175277-03-9 MFCD00068104

化学结构图

175277-03-9
SMILES: CC1N=C(SC=1C(=O)OCC)C1C=CC(=CC=1)C(F)(F)F

化学属性

Mol. FormulaC14H12F3NO2S
Mol. Weight315
Melting Point85-86°
TSCANo

别名和识别编码

Chemical NameEthyl 4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-Carboxylate
CAS Number175277-03-9
Alfabeta NameETHYLMETHYLTRIFLUOROMETHYLPHENYLTHIAZOLECARBOXYLATE 424135[]()--------,
MDL NumberMFCD00068104
Synonym 4-Methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester Ethyl 4-Methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylate Ethyl 4-methyl-2-[4-(trifluoro-methyl)-phenyl]thiazole-5-carboxylate
Chemical Name Translation4-甲基-2-(4-(三氟甲基)苯基)噻唑-5-羧酸乙酯
PubChem Substance ID329774610
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分类

  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • {SNA} Building Blocks, C12 to C20+, Chemical Synthesis, Heterocyclic Building Blocks, Thiazoles
  • Intermediates & Fine Chemicals
  • {KO} Esters

产品应用

  • Intermediate in the production of GW 501516 and its derivatives

相关文献及参考

  • Sierra, M., et al.: J. Med. Chem., 50, 685 (2007),

安全信息

Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
GHS Symbol
WGK Germany3
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Signal word Danger
Hazard Codes Xn

药物吸收、分布、代谢与排泄(ADME)

Lipinski's Rule of 5
Y
H-bond Acceptors
3
Rotatable Bonds
4
H-bond Donors
0
LogP
3

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Thiazoles 噻唑
  5. C12 to C20+ - Thiazoles

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