5'-(N-Ethylcarboxamido)adenosine 5’-Ethylcarboxamido

CAS 35920-39-9 MFCD00069195

化学结构图

35920-39-9
SMILES: CCNC(=O)C1OC(n2cnc3c(N)ncnc32)C(O)C1O

化学属性

Mol. FormulaC12H16N6O4
Mol. Weight308
TSCANo
Melting Point229-231°

别名和识别编码

Chemical Name5'-(N-Ethylcarboxamido)adenosine
CAS Number35920-39-9
Synonym 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethylribofuranuronamide hemihydrate 5' N Ethylcarboxamidoadenosine 5'-(N-Ethylcarboxamido)adenosine 5'-N(Sup 6)-Ethylcarboxamidoadenosine hemihydrate 5'-N-Ethylcarboxamidoadenosine 5'-N-Ethylcarboxamidoadenosine hemihydrate Adenosine 5' N ethyluronamide Adenosine, N6-Ethyl-carboxamido Adenosine-5'-(N-ethyl)carboxamide hemihydrate Adenosine-5'-(N-ethylcarboxamide) Adenosine-5'-N-ethyluronamide N Ethylcarboxamidoadenosine N-Ethylcarboxamidoadenosine N6 Ethyl carboxamido Adenosine N6-Ethyl-carboxamido Adenosine NECA NECA, 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-?-D-ribofuranuronamide
PubChem Substance ID448222
MDL NumberMFCD00069195
Wiswesser Line NotationT56 BN DN FN HNJ IZ D- BT5OTJ CQ DQ EVM2 &QH 1/2
Chemical Name Translation5’-Ethylcarboxamido
LabNetwork Molecule IDLN01817075
InChIKeyJADDQZYHOWSFJD-FLNNQWSLSA-N
InChIInChI=1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1
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分类

  • Bases & Related Reagents
  • Nucleotides
  • Inhibitors
  • {SNA} Adenosines/P2 Nucleotide Receptor - Agonists, Adenosines/P2 Nucleotide Receptors (Purinergics), Agonists, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, E, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives
  • {SNA} Adenosines/P2 Nucleotide Receptor - Agonists, Adenosines/P2 Nucleotide Receptors (Purinergics), Agonists, Bioactive Small Molecule Alphabetical Index, E, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Pr

产品应用

  • A potent adenosine receptor agonist. Inhibits platelet aggregation and is centrally active in vivo.

相关文献及参考

  • [2]. Elsherbiny NM, et al. Reno-protective effect of NECA in diabetic nephropathy: implication of IL-18 and ICAM-1. Eur Cytokine Netw. 2012 Jul-Sep;23(3):78-86.
  • Cusack and Hourani: Br. J. Pharmacol., 72, 433 (1981),
  • [1]. Knapp CM, et al. Adenosine agonists CGS 21680 and NECA inhibit the initiation of cocaine self-administration. Pharmacol Biochem Behav. 2001 Apr;68(4):797-803.
  • [1]. Knapp CM, et al. Adenosine agonists CGS 21680 and NECA inhibit the initiation of cocaine self-administration. Pharmacol Biochem Behav. 2001 Apr;68(4):797-803.
  • [2]. Elsherbiny NM, et al. Reno-protective effect of NECA in diabetic nephropathy: implication of IL-18 and ICAM-1. Eur Cytokine Netw. 2012 Jul-Sep;23(3):78-86.

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H300 Fatal if swallowed 吞食致命
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSVJ2232000
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P310
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Hazard Codes 6.1 T+
Risk Statements
  • R28 Very toxic if swallowed 吞咽极毒
Packing GroupII
UN Number 2811 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 23,313,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 23,313,1980

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Synthetic Oligonucleotides and Related Reagents - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Adenosines/P2 Nucleotide Receptors (Purinergics) - Neurotransmitters
  8. Agonists - Adenosines/P2 Nucleotide Receptors (Purinergics)
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adenosine Receptor  (腺苷受体)

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