Idazoxan (hydrochloride) 盐酸咪唑克生
CAS 79944-56-2 MFCD00069293
化学结构图
SMILES: Cl.C1OC2C=CC=CC=2OC1C1NCCN=1
化学属性
| Mol. Formula | C11H13ClN2O2 |
|---|---|
| Mol. Weight | 241 |
别名和识别编码
| Chemical Name | Idazoxan (hydrochloride) |
|---|---|
| CAS Number | 79944-56-2 |
| Synonym | (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride RX 781094 (+/-)-Idazoxan Monohydrochloride 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole Hydrochloride Idazoxan hydrochloride RX 781094 RX 781094A |
| MDL Number | MFCD00069293 |
| PubChem Substance ID | 24278493 |
| Chemical Name Translation | 盐酸咪唑克生 |
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分类
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, I, Imidazoline Binding Site Ligands, Neuroscience, Neurotransmission, Neurotransmitters
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Aromatics
- {SNA} Bioactive Small Molecule Alphabetical Index, I, Imidazoline Binding Site Ligands, Neuroscience, Neurotransmission, Neurotransmitters, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
产品应用
- An ?-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for ?2- over ?1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian
相关文献及参考
- [2]. Bousquet P, et al. Participation of imidazoline receptors and alpha(2-)-adrenoceptors in the central hypotensive effects of imidazoline-like drugs. Ann N Y Acad Sci. 1999 Jun 21;881:272-8.
- Fliri, A., et al.: Med. Chem., 48, 6918 (2005),
- Yildirim, M., et al.: Nat. Biotechnol., 25, 1119 (2007),
- [1]. Roberto W Invernizzi, et al. The α2-Adrenoceptor Antagonist Idazoxan Reverses Catalepsy Induced by Haloperidol in Rats Independent of Striatal Dopamine Release: Role of Serotonergic Mechanisms. Neuropsychopharmacology volume 28, pages872-879 (2003).
- [1]. Roberto W Invernizzi, et al. The α2-Adrenoceptor Antagonist Idazoxan Reverses Catalepsy Induced by Haloperidol in Rats Independent of Striatal Dopamine Release: Role of Serotonergic Mechanisms. Neuropsychopharmacology volume 28, pages872-879 (2003).
- [2]. Bousquet P, et al. Participation of imidazoline receptors and alpha(2-)-adrenoceptors in the central hypotensive effects of imidazoline-lik
安全信息
GHS Symbol
- P301+P310
- H301 Toxic if swallowed 吞食有毒
- S7 Keep container tightly closed 保存在严格密闭容器中；
- R22 Harmful if swallowed 吞咽有害
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