D-α-Hydroxyglutaric Acid Disodium Salt 2-羟基-D-谷氨酸二钠盐
CAS 103404-90-6 MFCD00069573
化学结构图
SMILES: [Na+].[Na+].[O-]C(=O)CC[C@@H](O)C([O-])=O
化学属性
| Mol. Formula | C5H6O5Na2 |
|---|---|
| Mol. Weight | 192.08 |
别名和识别编码
| Chemical Name | D-α-Hydroxyglutaric Acid Disodium Salt |
|---|---|
| CAS Number | 103404-90-6 |
| Synonym | (2R)-2-Hydroxypentanedioic Acid Disodium Salt (R)-2-羟基戊二酸 |
| MDL Number | MFCD00069573 |
| PubChem Substance ID | 24895823 |
| Chemical Name Translation | 2-羟基-D-谷氨酸二钠盐 |
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分类
- Amino Acid Derivatives, Cancer Metabolism, Cancer Research, Chemical Biology, Chemical Synthesis, Glutamic Acid, Isocitrate Dehydrogenase (IDH) Substrates and Reaction Products, Isocitrate Dehydrogenase (IDH) in Cancer Metabolism, Peptide Chemistry
- {SNA} Amino Acid Derivatives, Cancer Metabolism, Cancer Research, Chemical Biology, Chemical Synthesis, Glutamic Acid, Isocitrate Dehydrogenase (IDH) Substrates and Reaction Products, Isocitrate Dehydrogenase (IDH) in Cancer Metabolism, Peptide Chemistry
产品应用
- A potential inhibitor of glutamate carboxypeptidase.
相关文献及参考
- [2]. Fu X, et al. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell Metab. 2015 Sep 1;22(3):508-15.
- [3]. Martijn Kranendijk, et al. Progress in understanding 2-hydroxyglutaric acidurias. J Inherit Metab Dis. 2012 Jul;35(4):571-87.
- [4]. Martin Böttcher, et al. D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization. Oncoimmunology. 2018 Mar 26;7(7):e1445454.
- [5]. Alexandra Latini , et al. D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats. Eur J Neurosci. 2003 May;17(10):2017-22.
- Knowles, P.F., et al.: Eur. J. Biochem., 114, 139 (1981),
- Wolcott, T.G., et al.: Biochem. Biophys. Res. Commun., 57, 709 (1974),
- [1]. Xu W, et al. Onc
- [1]. Xu W, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.
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