Chloroquine Diphosphate Salt 磷酸氯喹

CAS 50-63-5 MFCD00069852

化学结构图

50-63-5
SMILES: CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12.O=P(O)(O)O.O=P(O)(O)O

化学属性

Mol. FormulaC18H32ClN3O8P2
Mol. Weight516
Melting Point200 °C (dec.)(lit.)
TSCANo
SolubilityDMSO <1 mg/mL Water 100 mg/mL Ethanol <1 mg/mL
Appearance solid

别名和识别编码

Chemical NameChloroquine Diphosphate Salt
MDL NumberMFCD00069852
CAS Number50-63-5
Synonym 3377 RP 7-CHLORO-4-OXO-1H-QUINOLINE-3-CARBOXYLIC ACID 7-Chlor-4-(4-(diaethylamino)-1-methylbutylamino)-chinolindiphosphat 7-Chloro-4-((4'-diethylamino-1-methylbutyl)amino)quinoline diphosphate 7-chlor-4-(4-(diaethylamino)-1-methylbutylamino)-chinolindiphosphat 7-chloro-4-((4’-diethylamino-1-methylbutyl)amino)quinolinediphosphate 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-quinolindiphosphate 7-氯-4-(4-二乙氨基-1-甲基丁氨基)喹啉二磷酸盐 Alermine Aralen Aralen phosphate Avloclor Bemaphate CHLOROQUINE DIPHOSPHATE CHLOROQUINE DIPHOSPHATE SALT CHLOROQUINE PHOSPHATE Chingamin Chingamin phosphate Chloroquine diphosphate Chloroquine phosphate Delagil Gontochin phospha H-Stad
Beilstein Registry Number4223142
EC Number200-055-2
PubChem Substance ID64927
Merck Number2163
Reaxys-RN4223142
Chemical Name Translation磷酸氯喹
Wiswesser Line NotationT66 BNJ EMY1&3N2&2 IG &P2-O6
LabNetwork Molecule IDLN01105681
InChIInChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
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分类

  • {SNA} Additional Standards, Analytical Standards, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards, Pharmacopeia & Metrolog
  • {SNA} Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antiparasitic / Antiprotozoal / Anthelminthic, Autophagy, Autophagy Inhibitors, Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Cell Signaling and Neuroscience,
  • {SNA} Antibiotics A to Z,
  • {SNA} Additional Standards, Analytical Standards, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards, Pharmacopeia & Metrological Institutes Standards, Secondary Pharmaceutical Standards, 分析/色谱

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
RTECSVB2450000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P301+P312+P330
  • P308+P313
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P330 Rinse mouth. 漱口
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Packing GroupIII
Hazard Class6.1(b)
UN Number 1544
Storage condition 储存温度-20°C 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 167 mg/kg
TOXIC EFFECTS :
   Cardiac - EKG changes not diagnostic of specified effects
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.19-    1982-  Volu

TYPE OF TEST            : TD

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 8 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2
   vols., Ann Arbor, MI, J.W. Edwards, 1946  Volume(issue)/page/year:
   1,390,1946

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 8571 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Gastrointestinal - other changes
REFERENCE :
   HUTODJ Human Toxicology.  (Macmillan Press Ltd., Houndmills, Basingstoke,
   Hants., RG 21 2XS, UK) V.1-    1981-  Volume(issue)/page/year: 8,387,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 68 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2
   vols., Ann Arbor, MI, J.W. Edwards, 1946  Volume(issue)/page/year:
   1,389,1946

TYPE OF TEST            : LDLo - Lowest p

TYPE OF TEST

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 200 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 192,233,1987

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 100 ug/L
REFERENCE :
   CBTOE2 Cell Biology and Toxicology.  (Princeton Scientific Pub., Inc., 301
   N. Harrison St., CN 5279, Princeton, NJ 08540)  V.1-    1984-
   Volume(issue)/page/year: 2,379,1986

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 ug/L
REFERENCE :
   CBTOE2 Cell Biology and Toxicology.  (Princeton Scientific Pub., Inc., 301
   N. Harrison St., CN 5279, Princeton, NJ 08540)  V.1-    1984-
   Volume(issue)/page/year: 2,379,1986

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2223 ug/disc
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 188,111,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 mg/plate
REFERENCE :
   CBTOE2 Cell Biology and Toxicology.  (Princeton Scientific Pub., Inc., 301
   N. Harrison St., CN 5279, Princeton, NJ 08540)  V.1-    1984-
   Volume(issue)/page/year: 2,379,1986

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 250 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 550 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 30,114,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1200 mg/kg
SEX/DURATION            : female 5-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 7,701,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 750 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 30,114,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 80 mg/kg
SEX/DURATION            : female 20-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - respira

其他信息

  • 氯喹 二磷酸盐
  • 用途一:抗疟药及抗阿米巴药，用于控制疟疾病状、疟疾症状控制性预防及阿米巴肝脓肿等
  • 磷酸氯喹价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C2301 磷酸氯喹 Chloroquine Diphosphate 500G 2690元 2014/06/02 C2301 磷酸氯喹 Chloroquine Diphosphate 25G 312元
  • MOL 文件:50-63-5.mol
  • 检测方法:T,NMR
  • Sigma Aldrich:50-63-5(sigmaaldrich)
  • F:10
  • 磷酸氯喹价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 C2301 磷酸氯喹 Chloroquine Diphosphate 500G 4090元 2011/04/16 C2301 磷酸氯喹 Chloroquine Diphosphate 25G 515元
  • 存储注意事项:光敏感

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Spectrum of Activity - Antibiotics
  4. Antiparasitic / Antiprotozoal / Anthelminthic - Spectrum of Activity
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Isoquinolines 异喹啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinaldines 奎纳丁
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinolines 喹啉
  1. Functional Group 官能团索引
  2. phosphoric acid

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