Meclofenamic Acid 甲氯芬那酸

CAS 644-62-2 MFCD00072053

化学结构图

644-62-2
SMILES: Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl

化学属性

Mol. FormulaC14H11Cl2NO2
Mol. Weight296.16

别名和识别编码

Chemical NameMeclofenamic Acid
CAS Number644-62-2
Synonym 2-((2,6-Dichloro-3-methylphenyl)amino)benzoic acid 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic Acid 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid Arquel Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)- Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, monosodium salt, monohydrate INF 4668 Meclofenamate Meclofenamate Sodium Meclofenamate Sodium Anhydrous Meclofenamate Sodium Monohydrate Meclofenamate, Sodium Meclofenamic Acid Meclofenamic acid Meclomen Meclophenamic acid N-(2,6-Dichloro-m-tolyl)anthranilic Acid N-(2,6-Dichloro-m-tolyl)anthranilic acid Sodium Meclofenamate
EC Number211-419-5
Chemical Name Translation甲氯芬那酸
Wiswesser Line NotationQVR BMR BG FG C1
Beilstein Registry Number2221428
PubChem Substance ID4037
InChIInChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)
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分类

  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Anti-inflammatory; antipyretic.

相关文献及参考

  • [2]. Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017.
  • [3]. Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84.
  • Juby, et al.: J. Med. Chem., 11, 111 (1968),
  • Rees, M.C.P., et al.: Lancet, 2, 541 (1988),
  • Winder, et al.: J. Pharmacol. Exp. Ther., 148, 422 (1965),
  • [1]. Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8.
  • [1]. Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8.
  • [2]. Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;2

安全信息

RTECSCB2900000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 109 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 148,422,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AGACBH Agents and Actions, A Swiss Journal of Pharmacology.  (Birkhaeuser
   Verlag, POB 133, CH-4010 Basel, Switzerland)  V.1-    1969/70-
   Volume(issue)/page/year: 7,481,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intrauterine
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 239 ng/kg
SEX/DURATION            : female 4 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 63,365,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - pig
DOSE                    : 15 mg/kg
SEX/DURATION            : female 16 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 65,157,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 200 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 38,238,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 2750 ug/kg
SEX/DURATION            : female 1-3 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # s

系列性分类

  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Gap Junction Protein  (间隙连接蛋白)

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