Sodium ((4-Aminophenyl)Sulfonyl)(Thiazol-2-Yl)Amide ((4-氨基苯基)磺酰)(噻唑-2-基)酰胺钠盐

CAS 144-74-1 MFCD00072133

化学结构图

144-74-1
SMILES: Nc1ccc(S(=O)(=O)N([Na])c2nccs2)cc1

化学属性

Mol. FormulaC9 H8 N3 O2 S2 . Na
Mol. Weight277.298
Boiling Point-
Flash Point-

别名和识别编码

Chemical NameSodium ((4-Aminophenyl)Sulfonyl)(Thiazol-2-Yl)Amide
MDL Number-
CAS Number144-74-1
Synonym (n(sup1)-2-thiazolylsulfanilamido)-sodiu 2-Sulfanilamidothiazole sodium salt 2-对氨基苯磺酰胺噻唑 LABO Monosodium 2-sulfanilamidothiazole N(sup 1)-2-Thiazolylsulfanilamide sodium salt SULFATHIAZOLE SULFATHIAZOLE SODIUM SULFATHIAZOLE SODIUM SALT Sodium 2-sulfanilamidothiazole Sodium norsulfazole Sodium sulfathiazole Sodium sulphathiazole Sulfanilamide, N(sup 1)-2-thiazolyl-, N(sup 1)-sodium deriv. Sulfathiazole Sodium Salt {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Beilstein Registry Number3802297
EC Number205-638-5
PubChem Substance ID12285822
Chemical Name Translation((4-氨基苯基)磺酰)(噻唑-2-基)酰胺钠盐
Wiswesser Line NotationT5N CSJ BMSWR DZ &-NA-
InChIInChI=1S/C9H8N3O2S2.Na/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9;/h1-6H,10H2;/q-1;+1
LabNetwork Molecule IDLN01871780
Canonical SMILES-
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分类

  • {SNA} Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Chemical Structure Class, Inhibits an Enzyme, Interferes with DNA Synthesis, L - Z, Mechanism of Action, Spectrum of Activity, Sulfonamides
  • {SNA} Antibacterial, Antibiotics A to Z,

安全信息

GHS Symbol
WGK Germany2
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSWP2450000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 45,15,1940

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 81,284,1944

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1950 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 43,328,1940

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 708 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIDXA3 Journal of the Indiana State Medical Association.  (Indiana State
   Medical Assoc., 3935 N. Meridian, Indianapolis, IN 46208)  V.1-    1908-
   Volume(issue)/page/year: 33,503,1940

TYPE OF TEST

{h

Storage condition -20 -20°C -20°C, Hygroscopic -20℃

其他信息

  • 用途一:属磺胺类药，用于治疗敏感菌感染
  • MOL 文件:144-74-1.mol
  • Sigma Aldrich:144-74-1(sigmaaldrich)
  • F:10

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics N-S - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Chemical Structure Class - Antibiotics
  4. Sulfonamides - Chemical Structure Class
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Mechanism of Action - Antibiotics
  4. Inhibits an Enzyme - Mechanism of Action
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Thiazoles 噻唑

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