Melengestrol acetate 醋酸美仑孕酮

CAS 2919-66-6 MFCD00072142

化学结构图

2919-66-6
SMILES: C=C1C[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]2(C)[C@@]1(OC(C)=O)C(C)=O

化学属性

Mol. FormulaC25H32O4
Mol. Weight396.52
Melting Point202-204 °C(lit.)
Appearance 淡黄色结晶粉末

别名和识别编码

Chemical NameMelengestrol Acetate
CAS Number2919-66-6
Synonym U-21240 17ALPHA-ACETOXY-6-METHYL-16-METHYLENE-4,6-PREGNADIENE-3,20-DIONE mga100(steroid) Melengestrol-acetate, Vetranal Melengestrol Acerate 甲烯雌醇乙酸酯 BDH 1921 6-diene-3,20-dione,17-hydroxy-6-methyl-16-methylene-pregna-acetate ######## 17α-acetoxy-6-methyl-16-methylene-4,6-pregnadiene-3,20-dione bdh1921 Melengestrol acetate 6-Dehydro-16-methylene-6-methyl-17-acetoxyprogesterone 美仑孕酮醋酸 5373 MGA 100 (steroid) Melengesterol acetate 17α-乙酰氧基-6-甲基-16-亚甲基-4,6-孕甾二烯-3,20-二酮 MGA mga100 17a-Acetoxy-6-methyl-16-methylene-4,6-pregnadiene-3,20-dione Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-methyl-16-methylene- MELENGOESTROLACETATE 醋酸美伦孕酮 MELENGESTROL ACETATE 20-dione,17-(acetyloxy)-6-methyl-16-methylene-pregna-6-diene-3 6-dehydro-16-methylene-6-methyl-17-acetoxyprogesterone 17α-乙酰氧基-6-甲基-16-亚甲基-4,6-孕甾二烯-3,20-二酮 MGA MGA 100 MELENGESTROL ACETATE 99% NSC-70968 17-(acetyloxy)-6-methyl-16-methylenepregna-4,6-diene-3,20-dione(9CI) 4,6-PREGNADIEN-6-METHYL-16-METHYLENE-17-OL-3,20-DIONE ACETATE
MDL NumberMFCD00072142
PubChem Substance ID57652468
Beilstein Registry Number2066919
EC Number220-859-7
Chemical Name Translation醋酸美仑孕酮
Wiswesser Line NotationL E5 B666 GY OV KU MUTJ A1 E1 FV1 FOV1 GU1 L1
LabNetwork Molecule IDLN01288189
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, M, MEA - MES, 分析/色谱
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, M, MEA - MES
  • Steroids,
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, M, MEA - MES

产品应用

  • Orally active progestational steroid. Progestogen; growth promotant.

相关文献及参考

  • Patton, M., et al.: Zoo Biol., 26, 311(2007),
  • Sellin, M., et al.: Environ. Toxicol. Chem., 28, 2443 (2009),
  • Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),

安全信息

RTECSTU4141000
GHS Symbol
Precautionary statements
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
WGK Germany3
Signal word Warning
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
Storage condition 0-6°C 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive -

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7500 ug/kg
SEX/DURATION            : female 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - breasts, lactation (prior to or during
   pregnancy)
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 9,138,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7500 ug/kg
SEX/DURATION            : female 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - uterus, cervix, vagina
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 9,138,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 40 mg/kg
SEX/DURATION            : male 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 15,419,1964

其他信息

  • Sigma Aldrich:2919-66-6(sigmaaldrich)
  • MOL 文件:2919-66-6.mol

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. M - Alphabetic
  5. MEA - MES - M

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