Aztreonam 氨曲南

CAS 78110-38-0 MFCD00072145

化学结构图

78110-38-0
SMILES: C[C@@H]1[C@@H](NC(=O)/C(=N\OC(C)(C)C(O)=O)/C2=CSC(N)=N2)C(=O)N1S(O)(=O)=O |&1:1,2|

化学属性

Mol. FormulaC13H17N5O8S2
Mol. Weight435

别名和识别编码

Chemical NameAztreonam
Synonym Antibiotic squibb 26,776 氨曲南 Monobactam SQ 26,776 [2S-[2α,3β(Z)]]-2-[[[1-(2-氨基-4-噻唑基)-2-[(2-甲基-4-氧代-1-磺基-3-氮杂环丁烷)氨基]-2-氧代亚乙基]氨基]氧代]-2-甲基丙酸 Azactam Squibb 26,776 Aztreonam Azthreonam [2S-[2α,3β(Z)]]-2-[[[1-(2-氨基-4-噻唑基)-2-[(2-甲基-4-氧代-1-磺基-3-氮杂环丁烷)氨基]-2-氧代亚乙基]氨基]氧代]-2-甲基丙酸
MDL NumberMFCD00072145
CAS Number78110-38-0
EC Number278-839-9
Reaxys-RN3577211
Merck Number925
Chemical Name Translation氨曲南
InChIKeyWZPBZJONDBGPKJ-VEHQQRBSSA-N
Beilstein Registry Number3577211
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分类

  • A, A - K, AR to AZ, Alphabetic, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, Neat Compounds, Others, Spectrum of Activity
  • {SNA} A, A - K, AR to AZ, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics, Biochemicals and Reagents, Chemical Structure,

相关文献及参考

  • Boucher, B.A., Role of aztreonam in the treatment of nosocomial pneumonia in the critically ill surgical patient. Am. J. Surg. 179 , 45, (2000) 摘要
  • Merck 14 ,925

安全信息

RTECSUA2451400
WGK Germany2
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 18,474,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3154 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   33(Suppl 1),143,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2549 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   33(Suppl 1),143,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibu

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2970 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   33(Suppl 1),203,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1100 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   33(Suppl 1),203,1985

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs of Abuse - Forensic and Veterinary Standards
  6. Chemical Structure - Drugs of Abuse
  7. Others - Chemical Structure
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. A - Alphabetic
  5. AR to AZ - A

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