2-Chloro-4,6-dimethoxy-1,3,5-triazine 2-氯-4,6-二甲氧基-1,3,5-三嗪

CAS 3140-73-6 MFCD00075607

化学结构图

3140-73-6
SMILES: COc1nc(Cl)nc(OC)n1

化学属性

Mol. FormulaC5H6ClN3O2
Mol. Weight175.57
Melting Point71-74 °C
TSCANo
Boiling Point215.1°C at 760 mmHg
Density1.422
Solubility不溶
Flash Point99-100°C/1mm
Appearance 白色结晶粉末,熔点 71-78°C,沸点 99-100°C (1 mmHg),水溶性 insoluble

别名和识别编码

Chemical Name2-Chloro-4,6-dimethoxy-1,3,5-triazine
CAS Number3140-73-6
Alfabeta NameCHLORODIMETHOXYTRIAZINE 246135-----,,,
MDL NumberMFCD00075607
Synonym Chlorodimethoxytriazine {LY} Chlorodimethoxytriazine {} {LY} Chlorodimethoxytriazine {} {} {LY} Chlorodimethoxytriazine {} {} {} {LY} Chlorodimethoxytriazine {} {} {} {} {LY} Chlorodimethoxytriazine {} {} {} {} {} {LY} Chlorodimethoxytriazine {} {} {} {} {} {} {LY} Chlorodimethoxytriazine {} {} {} {} {} {} {} {LY} Chlorodimethoxytriazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorodimethoxytriazine {} {} {} {} {} {} {} {} {} {LY} Chlorodimethoxytriazine {} {} {} {} {} {} {} {} {} {} {LY} Chlorodimethoxytriazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorodimethoxytriazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorodimethoxytriazine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorodimethoxytriazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorodimethoxytriazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorodimet
PubChem Substance ID18450
Beilstein Registry Number148988
EC Number221-541-0
Reaxys-RN148988
Chemical Name Translation2-氯-4,6-二甲氧基-1,3,5-三嗪
InChIKeyGPIQOFWTZXXOOV-UHFFFAOYSA-N
LabNetwork Molecule IDLN00008991
InChIInChI=1S/C5H6ClN3O2/c1-10-4-7-3(6)8-5(9-4)11-2/h1-2H3
Canonical SMILESCOC1=NC(=NC(=N1)OC)Cl
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分类

  • Building Blocks, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Triazines
  • {SNA} Building Blocks, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Triazines

产品应用

  • 一种稳定并且具高反应性的肽偶联剂

相关文献及参考

  • Reagent for activation of carboxylic acids to nucleophiles: J. Org. Chem., 63, 4248 (1998). Peptide coupling reagent: Synthesis, 917 (1987). With N-methylmorpholine forms the quaternary chloride (DMTMM) which is a valuable low-cost coupling agent in solid-phase peptide synthesis: Synlett, 275 (2000). For a reexamination of the use of the reagent in peptide coupling, see: Tetrahedron Lett., 42, 4161 (2002); see also Appendix 6.
  • Can also be used for the esterification of carboxylic acids: Synthesis, 593 (1999). The intermediate active esters can be hydrogenolyzed, providing a simple method for reduction of acids to aldehydes; at higher pressures, further reduction to the alcohol can be effected: J. Org. Chem., 64, 8962 (1999).
  • Similarly, carboxylic acids are converted to Weinreb amides by reaction with N,O-dialkyl hydroxylamines: J. Org. Chem., 66, 2534 (2001).

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P317
  • P302+P350
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P317
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P333+P313
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
Hazard Codes Xi
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning {} {} {} {} {} {} {} {} {} {} {} {TCI}
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37 Wear suitable gloves 戴适当手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition -20°C {LY} -20°C {} {LY} -20°C {} {} {LY} -20°C {} {} {} {LY} -20°C {} {} {} {} {LY} -20°C {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • 上游原料:甲醇 --> 石油醚 --> 碳酸氢钠 --> 三聚氯氰
  • Sigma Aldrich:3140-73-6(sigmaaldrich)
  • MSDS 信息:2-Chloro-4,6-dimethoxy-1,3,5-triazine(3140-73-6).msds
  • MOL 文件:3140-73-6.mol
  • 用途一:是稳定的，但活性极强的肽(缩氨酸)的偶合试剂，多用于多肽的合成
  • 检测方法:HPLC
  • Acros Organics:2-氯-4,6-二甲氧基-1,3,5-三嗪 2-Chloro-4,6-dimethoxy-1,3,5-triazine, 98%(3140-73-6)
  • Alfa Aesar:2-氯-4,6-二甲氧基-1,3,5-三嗪,98% 2-Chloro-4,6-dimethoxy-1,3,5-triazine, 98%(3140-73-6)
  • 2-氯-4,6-二甲氧基-1,3,5-三嗪价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C1676 2-氯-4,6-二甲氧基-1,3,5-三嗪 2-Chloro-4,6-dimethoxy-1,3,5-triazine 25G 2120元 2014/06/02 C1676 2-氯-4,6-二甲氧基-1,3,5-三嗪 2-Chloro-4,6-dimethoxy-1,3,5-triazine 250G 7370元 2014/06/02 C1676 2-氯-4,6-二甲氧基-1,3,5-三嗪 2-Chloro-4,6-dimethoxy-1,3,5-triazine 5G 624元
  • TCI Shanghai:2-氯-4,6-二甲氧基-1,3,5-三嗪 2-Chloro-4,6-dimethoxy-1,3,5-triazine,>;97.0%(LC)(T)(3140-73-6)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Thiophenes 噻吩
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Triazines 三嗪
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Triazines 三嗪
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Triazines - Halogenated Heterocycles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Triazines - Halogenated Heterocycles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Thiophenes