5-(N-2,3-Dihydroxypropylacetamido)-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide N,N'-双(2,3-二羟基丙基)-5-[N-(2,3-二羟基丙基)乙酰胺基]-2,4,6-三碘代异酞酰胺
CAS 66108-95-0 MFCD00077732
化学结构图
SMILES: CC(=O)N(CC(O)CO)C1C(I)=C(C(I)=C(C=1I)C(=O)NCC(O)CO)C(=O)NCC(O)CO
化学属性
| Mol. Formula | C19H26I3N3O9 |
|---|---|
| Mol. Weight | 821 |
别名和识别编码
| Chemical Name | 5-(N-2,3-Dihydroxypropylacetamido)-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide |
|---|---|
| CAS Number | 66108-95-0 |
| Synonym | 5-(N-2,3-Dihydroxypropylacetamido)-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide 5-[Acetyl(2,3-dihydroxypropyl)amino]-N,N?-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide Accudenz Exypaque Histodenz™ Iohexol Nycodenz Omnipaque Omnipaque 140 Omnipaque 240 Omnipaque 300 WIN 39424 |
| MDL Number | MFCD00077732 |
| PubChem Substance ID | 253660591 |
| Beilstein Registry Number | 2406632 |
| EC Number | 266-164-2 |
| Chemical Name Translation | N,N'-双(2,3-二羟基丙基)-5-[N-(2,3-二羟基丙基)乙酰胺基]-2,4,6-三碘代异酞酰胺 |
| Reaxys-RN | 2406632 |
| Merck Number | 5052 |
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分类
- {SNA} Centrifugation Media, Core Bioreagents, Density Gradient Media, Histopaque and Nonionic Iodinated Density Gradient Media, Other Nonionic Iodinated, Research Essentials, 细胞生物学, 血液学和组织学
- Labeling and Diagnostics Reagents,
- {SNA} Centrifugation Media, Core Bioreagents, Density Gradient Media and Cell Separation, Nonionic iodinated density gradient media, Research Essentials, 细胞生物学, 血液学和组织学
- {SNA} Centrifugation Media, Core Bioreagents, Density Gradient Media, Nonionic Iodinated Density Gradient Media, Research Essentials, 细胞生物学, 血液学和组织学
- {SNA} Centrifugation Media, Core Bioreagents,
产品应用
- Imaging agent.
相关文献及参考
- Wolf, G.L., et al.: Invest. Radiol., 16, 320 (1981),
- Mancini, G.B.J., et al.: Am. J. Cardiol., 51, 1218 (1983),
- Bettmann, M.A., et al.: Radiology, 153, 583 (1984),
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >20 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,105,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >20 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,105,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2200 mg/kg TOXIC EFFECTS : D
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 1400 mg/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 107,116,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 25235 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 370,41
- H315 Causes skin irritation 会刺激皮肤
GHS Symbol
- P302+P352+P332+P313+P362+P364
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P305+P351+P338+P337+P313
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