Monensin Sodium Salt 莫能霉素钠

CAS 22373-78-0 MFCD00077826

化学结构图

22373-78-0
SMILES: [Na+].C[C@]1(CCC2(C[C@H](O)[C@@H](C)[C@H](O2)[C@@H](C)[C@@H](OC)[C@H](C)C([O-])=O)O1)[C@H]1CC[C@](CC)(O1)[C@@H]1O[C@H](C[C@@H]1C)[C@H]1O[C@@](O)(CO)[C@H](C)C[C@@H]1C

化学属性

Mol. FormulaC36H61NaO11
Mol. Weight693
Melting Point267-269

别名和识别编码

Chemical NameMonensin Sodium Salt
Synonym Monensin 钠盐 Coban 45
CAS Number22373-78-0
PubChem Substance ID24896992
EC Number244-941-7
Beilstein Registry Number4122200
MDL NumberMFCD00077826
Chemical Name Translation莫能霉素钠
Wiswesser Line NotationT6OXTJ DQ E1 FY1&YO1&Y1&VQ B-& BT5OXTJ E1 E- ET5OTJB2 B- BT5OTJ
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分类

  • {SNA} Additional Standards, Analytical Standards, Antibacterial, Antibiotics A to Z, Antibiotics G-M, Antibiotics Standards, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antiparasitic / Antiprotozoal / Anthelminthic, Bactericidal, Chemical Structure, Chemical Structure Class, Chromatography, Clinical Standards, E numbers (Food Additives), E700–E799 (antibiotics), E714, Food & Beverage Standards, Food and Cosmetic Component Standards, Interferes with Cell Membrane Permeability (Ionophores), L - Z, MLS, Mechanism of Action, Pharmaceuticals

相关文献及参考

  • Callaway, T.R., et al., Selection of a highly monensin-resistant Prevotella bryantii subpopulation with altered outer membrane characteristics. Appl. Environ. Microbiol. 65 , 4753-4759, (1999) 摘要
  • Wang, X.D., et al., Phospholipase C activation by Na + /Ca 2+ exchange is essential for monensin-induced Ca 2+ influx and arachidonic acid release in FRTL-5 thyroid cells. J. Investig. Med. 47 , 388-396, (1999) 摘要
  • Nebbia, C., et al., Oxidative metabolism of monensin in rat liver microsomes and interactions with tiamulin and other chemotherapeutic agents: evidence for the involvement of cytochrome P-450 3A subfamily. Drug Metab. Dispos. 27 , 1039-1044, (1999) 摘要
  • Dmitrovic, J., and Durden, D.A., A New Approach To The Analysis Of Nicarbazin And Ionophores In Eggs By HPLC/MS/MS. J. AOAC Int. 94 , 428-35, (2011) 摘要

安全信息

GHS Symbol
WGK Germany3
Hazard Codes T
Hazard statements
  • H300 Fatal if swallowed 吞食致命
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSJH2830000
Precautionary statements
Signal word
Safety Statements
Risk Statements
UN Number
Packing GroupII 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - pig
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   58,1512,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc

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TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   58,1512,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 145 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   MBIID4 MBI, Mediko Biologicheskaya Informatsiya.  Medical-Biological
   Information.  ("Ivana Vazova" No. 3, Sofia 1000, Bulgaria)  1967-
   Volume(issue)/page/year: (3),3,1984

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics G-M - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Chemical Structure Class - Antibiotics
  4. Polyethers - Chemical Structure Class
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Voltage-gated Ion Channels - Ion Channels
  6. Monovalent Ion Channels - Voltage-gated Ion Channels
  7. Ionophores - Monovalent Ion Channels
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Antibiotics by Application
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Glycobiology
  4. Inhibitors and Substrates
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Chemical Structure Class
  5. Polyenes
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Mechanism of Action
  5. Inhibits an Enzyme
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Neuroscience
  5. Ion Channels
  6. Ligand-Gated Ion Channels
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteomics
  4. Post-Translational Modification
  5. Glycobiology
  6. Glycoprotein Detection
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Ion Channels
  5. Voltage-gated Ion Channels
  6. Monovalent Ion Channels
  7. Ion Pump Inhibitors

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