卡那霉素B 硫酸盐 卡那霉素B 硫酸盐
CAS 29701-07-3 MFCD00078511
化学结构图
SMILES: NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)[C@@H](O)[C@@H]1O.OS(O)(=O)=O
化学属性
| Mol. Formula | C18H37N5O10? |
|---|---|
| Mol. Weight | 484 |
别名和识别编码
| Chemical Name | D-Streptamine,O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4))-2-deoxy-, sulfate (1:1) |
|---|---|
| CAS Number | 29701-07-3 |
| Synonym | Bekanamycin sulfate Kanamycin B, sulfate (1:1) (salt) Kanamycin B sulfate salt Kanendomycin sulfate O-3-Amino-3-deoxy-?-D-glucopyranosyl-(1?6)-O-[2,6-diamino-2,6-dideoxy-?-D-glucopyranosyl-(1?4)]-2-deoxy-D-streptamine Sulfate Kanamycin B Sulfate Bekanamycin Sulfate Kanamycin B sulfate Aminodeoxykanamycin sulfate Ka Aminodeoxykanamycin Sulfate |
| MDL Number | MFCD00078511 |
| PubChem Substance ID | 24881934 |
| Beilstein Registry Number | 5235274 |
| Chemical Name Translation | 卡那霉素B 硫酸盐 |
| Wiswesser Line Notation | T6OTJ B1Q CQ DZ EZ FO- BL6TJ AZ CQ EZ DO- BT6OTJ CQDZ EQ F1Q &..H2.S-O4 |
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分类
- Amines
- Oligosaccharides
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} A - K, Aminoglycosides, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Chemical Structure Class, Interferes with Protein Synthesis, Mechanism of Action, Spectrum of Activity
产品应用
- Antibiotic complex produced by Streptomyces kanamyceticus Okami & Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congene
相关文献及参考
- Ito, et al.: J. Antibiot., 17, 189 (1964),
- Toda, S., et al.: J. Antibiot., 30, 1002 (1977),
- Claes, P.J., et al.: Anal. Profiles Drug. Subs., 6, 259 (1977),
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,742,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1900 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethi
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,742,1982
{TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 141 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,742,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5950 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Cardiac - other changes Lungs, Thorax, or Respiration - respiratory depression REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai
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