Pancuronium Dibromide 4-羟基-3-硝基苯胂酸

CAS 15500-66-0 MFCD00079223

化学结构图

15500-66-0
SMILES: [Br-].[Br-].C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](OC(C)=O)[C@H](C[C@@]43C)[N+]3(C)CCCCC3)[C@@H]1C[C@@H]([C@@H]2OC(C)=O)[N+]1(C)CCCCC1

化学属性

Mol. FormulaC35H60Br2N2O4
Mol. Weight733

别名和识别编码

Chemical NamePancuronium Dibromide
CAS Number15500-66-0
Synonym ######## 1,1′-[(2β,3α,5α,16β,17β)-3,17-bis(Acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide 1,1'-[(2b,3a,5a,16b,17b)-3,17-Bis(acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide 1,1'-[(2β,3α,5α,16β,17β)-3,17-bis(Acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide 1,1'-[(2β,3α,5α,16β,17β)-3,17-bis(Acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide Pancuronium bromide 5alpha-Androstan-3alpha,17beta-diol, 2beta,16beta-dipipecolinio-, Pancuronium bromide
MDL NumberMFCD00079223
PubChem Substance ID24278623
Beilstein Registry Number4226892
EC Number239-532-5
Chemical Name Translation4-羟基-3-硝基苯胂酸
Wiswesser Line NotationL E5 B666TJ A1 E1 FOV1 OOV1 G- AT6KTJ A1& P- AT6KTJA1 &E 2
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分类

  • {SNA} Antagonists,
  • {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cholinergics, Ion Channels, Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Neurotransmitters, Nicotinic Acetylcholine Receptor Modulators,
  • Steroids
  • Pharmaceuticals
  • {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cholinergics, Ion Channels, Ligand-Gated Ion Channels, Neuroscience,
  • Intermediates & Fine Chemicals
  • {SNA} Analytical Standards, EP Standards, EP Standards P - R, Pharmacopeia & Metrological Institutes Standards, 分析/色谱
  • {SNA}

产品应用

  • A potent steroidal neuromuscular blocking agent; muscle relaxant.

相关文献及参考

  • Buckett, W.R. et al.: Br. J. Pharmacol. Chemother., 32, 671 (1968); Mol, W.E.M. et al.: Biochem. Pharmacol., 44, 1453 (1992); Playfor, S.D. et al.: Paediatric Clin. Pharmacol., 553 (2006);

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P301+P310
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
RTECSTN4930000
Signal word Danger
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
UN Number 2811 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 167 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,353,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 21200 ug/kg
TOXI

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 63 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 5,715,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 202 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   SKKNAJ Sankyo Kenkyusho Nempo.  Annual Report of Sankyo Research
   Laboratories.  (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
   Tokyo 140, Japan)  No.15-    1963-  Volume(issue)/page/year: 22,187,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rode

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 36 ug/kg
SEX/DURATION            : female 8-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   SKKNAJ Sankyo Kenkyusho Nempo.  Annual Report of Sankyo Research
   Laboratories.  (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
   Tokyo 140, Japan)  No.15-    1963-  Volume(issue)/page/year: 22,187,1970

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. P - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Ligand-Gated Ion Channels - Ion Channels
  6. Nicotinic Acetylcholine Receptor Modulators - Ligand-Gated Ion Channels
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Substrate Analogs - Enzyme Inhibitors by Type
  1. Functional Group 官能团索引
  2. quaternary ammonium salt

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