Pyridostigmine bromide 溴化吡斯的明

CAS 101-26-8 MFCD00079283

化学结构图

101-26-8
SMILES: CN(C)C(=O)Oc1ccc[n+](C)c1.[Br-]

化学属性

Mol. FormulaC9H13BrN2O2
Mol. Weight261.12
Appearance 溴吡斯的明(101-26-8)为淡黄色至无色液体，溶于乙醇及水。
Melting Point153.0 to 157.0 deg-C

别名和识别编码

Chemical NamePyridostigmine bromide
MDL NumberMFCD00079283
CAS Number101-26-8
Synonym 吡斯的明 3-(Dimethylaminocarbonyloxy)-1-methylpyridinium bromide PYBR 吡啶斯的明 Pyridinium, 3-(((dimethylamino)carbonyl)oxy)-1-methyl-, bromide 3-Hydroxy-1-methylpyridinium bromide dimethylcarbamate (ester) 3-DIMETHYLAMINOCARBONYLOXY-N-METHYL-PYRIDINIUM BROMIDE 溴化 1-甲基-3-羟基吡啶二甲氨基甲酸酯 PYRIDOSTIGMINE BROMIDE 3-(dimethylcarbamyloxy)-1-methylpyridiniumbromide 3-(((dimethylamino)carbonyl)oxy)-1-methyl-pyridiniubromide 溴化3-二甲氨基甲酰氧基-1-甲基吡啶 Mestinon Ro 1-5130 溴化吡啶斯的明 dimethylcarbamicacidesterof3-hydroxy-1-methylpyridiniumbromide Pyridostigmine bromide; 3-[[(Dimethylamino)carbonyl]oxy]-1-methylpyridinium bromide kalymin 金丝桃素,金丝桃蒽酮 Pyridostigmine bromide 3-hydroxy-1-methylpyridiniumbromidedimethylcarbamate(ester) pyridinium,3-hydroxy-1-methyl-,bromide,dimethylcarbamate(ester) Regonal mestinonebromide pyridinium,3-hydroxyl-1-methyl-,bromide,dimethylcarbamate 溴化 1-甲基-3-羟基吡啶鎓二甲氨基甲酸酯 溴吡斯的明 kalimin Kalimin 3-(DIMETHYLAMINOCARBONYLOXY)-1-METHYLPYRIDINIUM BROMIDE regonal 1-methyl-3-hydroxypyridiniumbromidedimethylcarbamate Mestinone bromide mestinon 3-二甲胺基酰氧基吡啶 3-(DIMETHYLCARBAMOYLOXY)-1-METHYLPYRIDINIUM BROMIDE Dimethylcarbamic acid ester of 3-hydroxy-1-methylpyridinium bromide mestinonbromide 3-hydroxy-1-methylpyridiniumbromidedimethylcarbamate ro1-5130
PubChem Substance ID7550
EC Number202-929-9
Reaxys-RN3764573
Merck Number7977
Chemical Name Translation溴化吡斯的明
Wiswesser Line NotationT6KJ A1 COVN1&1 &E
LabNetwork Molecule IDLN00226106
InChIInChI=1S/C9H13N2O2.BrH/c1-10(2)9(12)13-8-5-4-6-11(3)7-8;/h4-7H,1-3H3;1H/q+1;/p-1
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分类

  • {SNA} Analytical Standards,
  • {SA} A to C, Acetylcholinesterase, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cholinesterase, acetyl, Cholinesterase, butyryl, Enzyme Inhibitors,
  • {SNA} A to C, Acetylcholinesterase, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
  • {SNA} Analytical Standards, Pharmacopeia Metrological Institutes Standards, USP Standards, USP Standards P - R, 分析/色谱
  • {SNA} Analytical Standards, EP Standards, EP Standards P - R,

相关文献及参考

  • Merck 14 ,7977

安全信息

RTECSUU5270000
WGK Germany3
GHS Symbol
Precautionary statements
  • P301+P310+P330
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P405 Store locked up. 上锁保管。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P350
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
Signal word Danger
Hazard statements
  • H330 Fatal if inhaled 吸入致命
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H310 Fatal in contact with skin 皮肤接触致命
  • H300 Fatal if swallowed 吞食致命
Hazard Codes T+
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
UN Number UN 2811 6.1/PG 2 2811
Packing GroupII
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Hazard Class6.1 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MECHAN Medicinal Chemistry, A Series of Reviews.  (New York, NY)  V.1-6,
   1951-63.  Discontinued.  Volume(issue)/page/year: 3,329,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2699 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   4,S195,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 9 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - fasciculations
REFERENCE :
   IJMDAI Israel Journal of Medical Sciences.  (POB 1435, Jerusalem 91013,
   Israel)  V.1-    1965-  Volume(issue)/page/year: 27,659,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 26,145,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 630 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 69,291,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 280 mg/kg
SEX/DURATION            : female 15-21 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 69,291,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Effects on Newborn - physical
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 69,291,1991

其他信息

  • 用途一:抗胆碱酯酶药，用于重症肌无力、手术后功能性肠胀气及尿潴留
  • MSDS 信息:Mestinon(101-26-8).msds
  • MOL 文件:101-26-8.mol
  • TCI Shanghai:溴化吡斯的明 Pyridostigmine Bromide,>;98.0%(T)(101-26-8)
  • 溴吡斯的明价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 P1339 溴吡斯的明 Pyridostigmine Bromide 5G 1560元 2014/06/02 P1339 溴吡斯的明 Pyridostigmine Bromide 25G 4560元
  • Sigma Aldrich:101-26-8(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. A to C - Enzyme Inhibitors by Enzyme
  7. Cholinesterase, acetyl - A to C
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. A to C - Enzyme Inhibitors by Enzyme
  7. Cholinesterase, butyryl - A to C
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Pyridinium Compounds

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