Guanethidine Sulfate 硫酸胍

CAS 60-02-6 MFCD00079332

化学结构图

60-02-6
SMILES: N=C(N)NCCN1CCCCCCC1.N=C(N)NCCN1CCCCCCC1.O=S(=O)(O)O

化学属性

Mol. FormulaC10H22N4?1/2H2SO4
Mol. Weight247

别名和识别编码

Chemical NameGuanethidine Sulfate
CAS Number60-02-6
Synonym Guanidine, (2-(octahydro-1-azocinyl)ethyl)-, sulfate (2:1) Ismelin sulfate Oktatenzin Sanotensin Iporal 胍乙啶半硫酸盐 Isobarin (2-(Hexahydro-1(2H)-azocinyl)ethyl)guanidine sulfate Guethine SU-5864 Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, sulfate Octatensin (2-(Octahydro-1-azocinyl)ethyl)guanidine sulfate Sanoten Oktadin NSC 29863 beta-1-Azacyclooctylethylguanidine sulfate Guanetidin sulfate Octadine Guanetidin Sulfate Octadin Azocine, 1-(2-guanidinoethyl)octahydro-, sulfate (2:1) N-[2-(Hexahydro-1(2H)-azocinyl)ethyl]guanidine Sulfate Guanethidine sulfate NSC-29863 Guanethidine bisulfate
Chemical Name Translation硫酸胍
Wiswesser Line NotationT8NTJ A2MYZUM & 2WSQQ
PubChem Substance ID65328
InChIInChI=1S/2C10H22N4.H2O4S/c2*11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h2*1-9H2,(H4,11,12,13);(H2,1,2,3,4)
MDL Number
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分类

  • Amines
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Antihypertensive; antiglaucoma

相关文献及参考

  • Al-Shora, H., et al.: Int. J. Pharm., 47, 209 (1988),
  • Golander, Y., et al.: J. Pharm. Sci., 77, 902 (1988),

安全信息

RTECSMF3240000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 128,22,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 112 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   URXXAF U.S.S.R. Patent Document.  (Gosudarstvennyi Komitet SSSR po Delam
   Izobretenii i Otkrytii, Malyi Tcherkasski pereulok 2/6, Moscow, Russia).
   Volume(issue)/page/year: #0822829

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 128,22,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#08547

TYPE OF TEST            : LD50 - Letha

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE                    : 391 mg/kg
SEX/DURATION            : male 78 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   JSXRAJ Journal of Sex Research.  (Soc. for the Scientific Study of Sex,
   Inc., Mt. Royal & Guilford Aves., Baltimore, MD 21202)  V.1-    1965-
   Volume(issue)/page/year: 3,69,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1400 mg/kg
SEX/DURATION            : male 56 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   BJPCBM British Journal of Pharmacology.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.34-    1968-  Volume(issue)/page/year:
   48,30,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 900 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating
                          female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 56,715,1979

系列性分类

  1. Functional Group 官能团索引
  2. sulfuric acid

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