Alcohol dehydrogenase 乙醇脱氢酶

CAS 9031-72-5 MFCD00081305

化学结构图

9031-72-5
SMILES: CCC=CCC=CCC=CCC=CCC=CCCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OCC1OC(n2cnc3c(N)ncnc32)C(O)C1OP(=O)([O-])[O-]

化学属性

Mol. Formula-
TSCANo
Mol. Weight-

别名和识别编码

Synonym ADH ADH Alcohol Dehydrogenase from horse liver Alcohol:NAD+ oxidoreductase HLADH ADH 乙醇:NAD+ 氧化还原酶 醇脱氢酶 来源于酵母 ADH 乙醇:NAD+ 氧化还原酶; Alcohol Dehydrogenase Alcohol Dehydrogenase (NAD+) Alcohol Dehydrogenase I Alcohol Dehydrogenase II Alcohol Dehydrogenase equine Alcohol Dehydrogenase, Yeast Alcohol NAD+ Oxidoreductase Alcohol-NAD+ Oxidoreductase Alcohol-dehydrogenase from Yeast [for Blood alcohol-test] Dehydrogenase, Alcohol Dehydrogenase, Yeast Alcohol Oxidoreductase, Alcohol-NAD+ Yeast Alcohol Dehydrogenase {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} Yeast Alcohol Dehydrogenase {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} Oxidoreductase, Alcohol-NAD+ {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} Dehydro
MDL NumberMFCD00081305
CAS Number9031-72-5
EC Number232-870-4
PubChem Substance ID78120390
Chemical NameAlcohol Dehydrogenase
Chemical Name Translation乙醇脱氢酶
InChIInChI=1S/C43H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-31(51)26-34(53)72-25-24-45-33(52)22-23-46-41(56)38(55)43(2,3)28-65-71(62,63)68-70(60,61)64-27-32-37(67-69(57,58)59)36(54)42(66-32)50-30-49-35-39(44)47-29-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,29-30,32,36-38,42,54-55H,4,7,10,13,16,19-28H2,1-3H3,(H,45,52)(H,46,56)(H,60,61)(H,62,63)(H2,44,47,48)(H2,57,58,59)/p-4
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分类

  • {SNA} 1.1.x.x Acting on hydroxyl groups, 1.x.x.x Oxidoreductases, Alcohol Metabolism, Application Index, Clinical Chemistry, Diagnostic and Analytical Enzymes, Enzyme Class Index, Enzymes for Diagnostic Kit Manufacturing, General Metabolic Enzymes, 代谢组学, 生化试剂, 细胞生物学,

产品应用

  • 分子量为 141kDa 的四聚体包含了 4 个相同的亚基。每个亚基的活性位点都含有一个锌原子。每个活性位点还含有 2 个反应性巯基以及一个组氨酸残基。
  • 等电点：5.4-5.8
  • 最适 pH：8.6-9.0
  • 底物：酵母乙醇脱氢酶与乙醇最易反应，它的反应活性随着醇体积增大或减小而降低。与支链醇和仲醇的反应活性也非常低。
  • KM（乙醇）= 2.1×10-3M
  • KM（甲醇）= 1.3×10-1M
  • KM（异丙醇）= 1.4×10-1M
  • 抑制剂：能与游离巯基反应的化合物，包括 N-烷基马来酰亚胺和碘乙酰胺。
  • 锌螯合剂的抑制剂，包括 1,10-菲咯啉、
  • 8-羟喹啉、2,2′-联吡啶以及硫脲。
  • 底物类似物抑制剂，包括 β-NAD 类似物、嘌呤和嘧啶衍生物、氯乙醇以及氟乙醇。
  • 吸光系数：E1% = 14.6（水，280nm）

相关文献及参考

  • 1. S. Hayward, A. Kitao, Molecular dynamics simulations of NAD+-induced domain closure in horse liver alcohol dehydrogenase Biophys. J. 91 , 1823-1831, (2006) 摘要
  • 2. H. Eklund et al., Structure of a triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9A resolution J. Mol. Biol. 146 , 561-587, (1981) 摘要
  • 3. H. Eklund et al., Crystallographic investigations of nicotinamide adenine-dinucleotide binding to horse liver alcohol-dehydrogenase Biochemistry 23 , 5982-5996, (1984) 摘要
  • 4. F. Colonna-Cesari et al, Interdomain motion in liver alcohol dehydrogenase: Structural and energetic analysis of the hinge bending mode J. Biol. Chem. 261 , 15273-15280, (1986) 摘要

安全信息

Personal Protective Equipment Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany3
Storage condition <;0 <0°C 储存温度-20°C
RTECSSZ5999500
GHS Symbol
Safety Statements
Precautionary statements
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P352
  • P304+P340
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P333+P317
  • P342+P316
  • P362+P364
  • P403 Store in a well-ventilated place. 储存在通风良好的地方。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Diagnostic and Analytical Enzymes - Application Index
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Organic Synthesis and Immobilized Enzymes - Application Index
  6. Immobilized Enzymes - Organic Synthesis and Immobilized Enzymes
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Class Index - Enzymes, Inhibitors, and Substrates
  5. 1.x.x.x Oxidoreductases - Enzyme Class Index
  6. 1.1.x.x Acting on hydroxyl groups - 1.x.x.x Oxidoreductases
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Enzyme

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