Sodium L-Ascorbate L-抗坏血酸钠

CAS 134-03-2 MFCD00082340

化学结构图

134-03-2
SMILES: O=C1O[C@H]([C@@H](O)CO)C([O-])=C1O.[Na+]

化学属性

Mol. FormulaC6H7NaO6
Mol. Weight198.11
Melting Point220 °C
TSCAYes
Solubility620 G/L (20 ºC)
Density1.799
Appearance powder 抗坏血酸钠(134-03-2)为白色细微结晶体。熔点为218℃（分解）。易溶于水。无嗅，稍带咸味。其水溶液当pH值>;6时不稳定，会很快被空气氧化。
Refractive index105.5 ° (C=10, H2O)
Stability对光和湿度敏感
Boiling Point235 °C at 760 mmHg

别名和识别编码

Chemical NameSodium L-Ascorbate
Synonym L-Ascorbic acid (sodium salt) {LY} L-Ascorbic acid (sodium salt) {} {LY} L-Ascorbic acid (sodium salt) {} {} {LY} L-Ascorbic acid (sodium salt) {} {} {} {LY} L-Ascorbic acid (sodium salt) {} {} {} {} {LY} L-Ascorbic acid (sodium salt) {} {} {} {} {} {LY} L-Ascorbic acid (sodium salt) {} {} {} {} {} {} { {} {} {} {} {} {} {LY} L-Ascorbic acid (sodium salt) {} {} {} {} {} {} {} {LY} L-Ascorbic acid (sodium salt) {} {} {} {} {} {} {} {} {LY} L-Ascorbic acid (sodium salt) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Ascorbic acid (sodium salt) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Ascorbic acid (sodium salt) {} {} {} {} {} {} {} {} {} {} {} {LY} L-Ascorbic acid (sodium salt) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Ascorbic acid (sodium salt) {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Ascorbic acid (sodium salt) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL NumberMFCD00082340
CAS Number134-03-2
PubChem Substance ID23667548
Beilstein Registry Number3767246
EC Number205-126-1
Reaxys-RN5465157
Merck Number14,830
Chemical Name TranslationL-抗坏血酸钠
Wiswesser Line NotationT5OV EHJ CQ DQ EYQ1Q &-NA-
LabNetwork Molecule IDLN00336606
InChIInChI=1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1
Canonical SMILESO[C@@H](CO)[C@]1([H])C(O[Na])=C(O)C(O1)=O
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分类

  • {SNA} Carbohydrate Chemistry, Carbohydrate Derivatives, Chemical Biology, Chemical Synthesis, Nutrition Research, Vitamin C, Vitamins, 细胞生物学
  • {SNA} Amino Acids and Vitamins, Bioactives and Supplements for Stem Cell Expansion,
  • {SNA} Ascorbate, Biochemicals and Reagents, Cell Biology, Chemical Biology, Chemical Synthesis, Click Chemistry: Catalysts, Ligands and Reagents, Cofactor, Cofactors,
  • {SNA} Carbohydrate Chemistry, Carbohydrate Derivatives, Cell Biology, Chemical Biology,
  • {SNA} Carbohydrate Chemistry,
  • {SNA} Amino Acids and Vitamin
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutic
  • {SNA} Analytical St
  • {SNA} Ascor

相关文献及参考

  • [2]. Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.
  • [3]. Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83.
  • [4]. Yang X, et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50.
  • [5]. Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7.
  • [6]. Takagi H, et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53.
  • Duarte TL, Lun

安全信息

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSCI7671000
WGK Germany1
Signal word Warning
GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
Storage condition 2-8°C, sealed storage, away from moisture and light {LY} 2-8°C, sealed storage, away from moisture and light Store at RT. {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moistu 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 12500 nmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 375,195,1997

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 6250 nmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 375,195,1997

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 3500 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 60,321,1979

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 500 umol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   8,299,1980

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 60,321,1979

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 60,321,1979

TYPE OF TEST

TYPE OF TEST            : Unscheduled DNA synthesi

其他信息

  • 所属类别二:食品添加剂: 营养强化剂: 维生素类
  • 用途一:作食品营养强化剂，作用与抗坏血酸相同，使用量需经折算。此外还可作护色剂和抗氧化剂。
  • color:white to slightly yellow
  • 图谱信息:抗坏血酸钠(134-03-2)红外图谱(IR1) 抗坏血酸钠(134-03-2)红外图谱(IR
  • 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
  • 类别:有毒物品
  • 所属类别一:食品添加剂: 营养强化剂（营养增补剂）: 维生素
  • 使用限量:GB 14880—94：同“0100l，L-抗坏血酸”。 GB 2760-2001：糖果用香精0.1g/kg。 FAO/WHO(1984)：即食肉汤、羹，1000mg/kg；午餐肉、熟肉末、熟猪肩肉、熟洋火腿、婴儿食品罐头、婴儿和儿童谷物产品，500mg/kg；速冻龙虾，速冻鲈铀、鳕和黑线鳕、扁鱼、无须鳕等鱼片，1g/kg(以抗坏血酸计)。
  • Alfa Aesar:L-抗坏血酸钠,99% L-Ascorbic acid sodium salt, 99%(134-03-2)
  • TCI Shanghai:L-抗坏血酸钠 Sodium L-Ascorbate,>;98.0%(T)(134-03-2)
  • Acros Organics:维生素C钠盐 L-Ascorbic acid sodium salt, 99%(134-03-2)
  • 上游原料:维生素 C
  • MSDS 信息:L-Ascorbic acid sodium salt(134-03-2).msds
  • 参考质量标准一:GB 16313-1996 含量(以C6H7NaO6干燥品计)/% 99.0~101.0 比旋光度α D 25 +103°～+108° 干燥失重/% ≤0.25 重金属(以Pb计)/% ≤0.002 铅(以Pb计)/% ≤0.001 砷(以As计)/% ≤0.0003 pH值 7.0～8.0
  • 可燃性危险特性:可燃; 燃烧产生有毒钠氧化物烟雾
  • Sigma Aldrich:134-03-2(sigmaaldrich)
  • 下游产品:维生素 C
  • 储运特性:通风低温干燥
  • 易溶于水。无嗅，稍带咸味。其水溶液当pH值>6时不稳定，会很快被空气氧化。水中溶解度:620 g/l (20°C); 温水: 78 g/100ml。
  • 含量分析:将预先在真空干燥器(硫酸)中干燥24
  • 参考质量标准二:指标名称 FAO/WHO GB 16313—96 含量(干燥后) ≥99% 99.0%～101.0% 比旋光度[α] D 25 (10%W/V试液) +103°～+108° +103°～+108° Ph值(10%溶液) 6.5～8.0 7.0～8.0 干燥失重(H2SO4，24h) ≤0.25% ≤0.25% 砷(以As计，G
  • 抗坏血酸钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 67001982 L（+）抗坏血酸钠 100g 245元 2011/04/16 A0539 L-抗坏血酸钠 Sodium L-Ascorbate 25G 218元 2011/04/16 A0539 L-抗坏血酸钠 Sodium L-Ascorbate 500G 560元
  • 比旋光度:104 ° (c=1, H2O 25 °C)
  • 毒性:ADI不作特殊规定(FAO/WHO，2001)。 LD 50 ≥5g/kg(大鼠，经口)。 GRAS(FDA，§182．3731，2000)。
  • 方法一:在抗坏血酸的溶液中加入碳酸氢钠，放置片刻后添加异丙醇，沉淀即得产品。 将抗坏血酸溶于有机溶剂，加入碳酸钠加热使其反应，冷却后析出，过滤即得产品。
  • 用途二:该品的作用与抗坏血酸大致相同，用作各种食品的维生素C强化剂，可用于清凉饮料和奶制品。还用在火腿、腊肠等食品中，以保持血色和新鲜度。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Carbohydrate Chemistry - Chemical Biology
  4. Carbohydrate Derivatives 碳水化合物衍生物
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Carbohydrate Chemistry - Chemical Biology
  4. Carbohydrate Derivatives 碳水化合物衍生物
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Stem Cell Biology - Cell Biology
  4. General Stem Cell Biology - Stem Cell Biology
  5. Stem Cell Differentiation - General Stem Cell Biology
  6. Bioactives/Supplements - Stem Cell Differentiation
  7. Vitamins, Hormones, Misc. - Bioactives/Supplements
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Pathways - Metabolomics
  4. Metabolites and Cofactors on the Metabolic Pathways Chart - Metabolic Pathways
  5. Cofactor - Metabolites and Cofactors on the Metabolic Pathways Chart
  6. Ascorbate - Cofactor
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Pathways - Metabolomics
  4. Metabolites and Cofactors on the Metabolic Pathways Chart - Metabolic Pathways
  5. Cofactor - Metabolites and Cofactors on the Metabolic Pathways Chart
  6. Ascorbate - Cofactor
  1. Functional Group 官能团索引
  2. enediol
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Amino Acids and Vitamins
  4. Amino Acids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Vitamins
  4. Vitamin B7
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Culture
  4. Amino Acids and Vitamins
  5. Amino Acids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cofactors
  5. Other Cofactors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Reagents and Supplements
  4. Amino Acids and Vitamins
  5. Amino Acids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Culture
  4. Reagents and Supplements
  5. Amino Acids and Vitamins
  6. Amino Acids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Pathways
  5. Metabolites and Cofactors on the Metabolic Pathways Chart
  6. Cholesterol
  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)