2-(Diethylamino)Ethyl 3-Amino-4-Propoxybenzoate Hydrochloride 2-二乙基氨基乙基-3-氨基-4-丙氧基-苯甲酸酯盐酸盐

CAS 5875-06-9 MFCD00083467

化学结构图

5875-06-9
SMILES: CCCOc1ccc(C(=O)OCCN(CC)CC)cc1N.Cl

化学属性

Mol. FormulaC16H26N2O3.HCl
Mol. Weight330.85
Density1.065
SolubilityDMSO 12 mg/mL Water 66 mg/mL Ethanol <1 mg/mL
Melting Point182.0 to 186.0 deg-C

别名和识别编码

Chemical Name2-(Diethylamino)Ethyl 3-Amino-4-Propoxybenzoate Hydrochloride
CAS Number5875-06-9
Synonym ophthetic PROXYMETACAINEHYDROCHLORIDE/PROPARACAINE 丙美卡因 盐酸盐 3-Amino-4-propoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride benzoicacid,3-amino-4-propoxy-,2-(diethylamino)ethylester,monohydrochlorid ophthainehydrochloride Ophthaine hydrochloride Proxymetacaine hydrochloride 3-Amino-4-propoxybenzoic Acid 盐酸丙美卡因 ophthain benzoicacid,3-amino-4-propoxy-,2-(diethylamino)ethylester,hydrochloride chibro-heracaine ProxymetacaineHCL2-CHLORO-9-(2'-DEOXY-2'-FLUORO-B-D-ARABINOFURANOSYL)ADENINE PROPARACAINE HCL Alcaine 2-Diethylaminoethyl 3-amino-4-propoxybenzoate hydrochloride 烟酸丙美卡因 beta-(Diethylamino)ethyl 3-amino-4-n-propoxybenzoate hydrochloride 2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate; 3-Amino-4-propoxybenzoic acid 2-(diethylamino)ethyl ester; Ophthaine; Proparacaine 2-二乙基氨基乙基 3-氨基-4-丙氧基-苯甲酸酯盐酸盐 PROPARACAINE HYDROCHLORIDE alcaine PROXYMETACAINE(2-DIETHYLAMINOETHYL-3-AMINO-4-PROPOXYBENZOATE HYDROCHLORIDE) 盐酸丙美卡因; 丙美卡因盐酸盐; 2-二乙基氨基乙基 3-氨基-4-丙氧基-苯甲酸酯盐酸盐 beta-(diethylamino)ethyl3-amino-4-n-propoxybenzoatehydrochloride Proxymetacaine Proparacaine hydrochloride 2-diethylaminoethyl 3-amino-4-propoxy-benzoate hydrochloride Keracaine 丙美卡因盐酸盐 Ophthain 3-amino-4-propoxybenzoicacid2-(diethylamino)ethylesterhydrochloride keracaine
MDL NumberMFCD00083467
PubChem Substance ID253662420
EC Number227-541-7
Chemical Name Translation2-二乙基氨基乙基-3-氨基-4-丙氧基-苯甲酸酯盐酸盐
Reaxys-RN3754950
Merck Number7807
Wiswesser Line Notation3OR BZ DVO2N2&2 &GH
LabNetwork Molecule IDLN01310892
InChIInChI=1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Pharmaceuticals
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, Neat Compounds, Others, P, PON - PT
  • Intermediates & Fine Chemicals,

产品应用

  • Topical anesthetic (ophthalmic).

相关文献及参考

  • McIntyre, S., et al.: J. Pharmacol. Exp. Ther., 63, 369 (1938),
  • Whigan, D.B., et al.: Anal. Profiles Drug Subs., 6, 423 (1977),

安全信息

RTECSDG3065000
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P305+P351+P338
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Hazard Codes Xn
Risk Statements
  • R36 Irritating to eyes 刺激眼睛
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Storage condition 储存温度-20°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3371 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 123,269,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 64 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 40,133,1982

其他信息

  • Proparacaine HCl是电压门控的钠离子通道的拮抗剂，ED50是3.4 mM。
  • MOL 文件:5875-06-9.mol
  • Sigma Aldrich:5875-06-9(sigmaaldrich)

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs &amp; Metabolites - Forensic and Veterinary Standards
  6. Neat Compounds - Drugs &amp; Metabolites
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. P - Alphabetic
  5. PON - PT - P

相关产品推荐