Thapsigargin 毒胡萝卜素, 来源于毒胡萝卜
CAS 67526-95-8 MFCD00083511
化学结构图
SMILES: C[C@@]1(O)C(=O)O[C@H]2C3[C@H]([C@H](OC(=O)CCCCCCC)[C@@H](OC(=O)/C(/C)=C\C)C=3C)[C@](C)(C[C@H](OC(=O)CCC)[C@]12O)OC(C)=O
化学属性
| Mol. Formula | C34H50O12 |
|---|---|
| Mol. Weight | 651 |
别名和识别编码
| Chemical Name | Thapsigargin |
|---|---|
| CAS Number | 67526-95-8 |
| Synonym | ######## |
| PubChem Substance ID | 24278762 |
| MDL Number | MFCD00083511 |
| Chemical Name Translation | 毒胡萝卜素, 来源于毒胡萝卜 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- Heterocycles
- {SNA} A to C, Adenosinetriphosphatase (microsomal calcium), Autophagy, Autophagy Inhibitors, Bioactive Small Molecule Alphabetical Index, Chemical Activators and Inhibitors of ER Stress, Endoplasmic Reticulum Stress, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Intracellular Calcium Regulators, Intracellular Calcium Signaling, Isoprenoids, Prenols, T, Therapy Adjuncts, 抗肿瘤药物, 生化试剂, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 脂类, 酶、抑制剂和底物
- Inhibitors
- {SNA} A to C, Adenosinetripho
产品应用
- ########
相关文献及参考
- Treiman, M. et al.: Trends Pharmacol. Sci., 19, 131 (1998); Korge, P. et al.: Eur. J. Biochem., 265, 273 (1999); Tsukamoto, A. Cell Biol. Int., 17, 969 (1993); Kutinova C.N. et al.: Cell Biol. Toxicol
- Treiman, M., et al., A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca 2+ -ATPases. Trends Pharmacol. Sci. 19 , 131-135, (1998) 摘要
- Korge, P. and Weiss, J.N., Thapsigargin directly induces the mitochondrial permeability transition. Eur. J. Biochem. 265 , 273-280, (1999) 摘要
- Thomas, G.R., et al., Thapsigargin inhibits a potassium conductance and stimulates calcium influx in the intact rat lens. J. Physiol. London, England 516 , 191-199, (1999) 摘要
- Sekiguchi-Tonosaki, M., et al., Acetylcholine Induces Ca2+ Signaling In Chicken Retinal Pigmented Epithelial Cells During Dedifferentiation. Am. J. Physiol. Cell Physiol. 296 , C1195-206, (2009) 摘要
- Kerbiriou, M., et al., The Calpain, Caspase 12, Caspase 3 Cascade Leading To Apoptosis Is Altered In F508del-CFTR Expressing Cells. PLoS ONE 4 , e8436, (2009) 摘要
- Brisac, C., et al., Calcium Flux Between The Endoplasmic Reticulum And Mitochondrion Contributes To Poliovirus-induced Apoptosis. J. Virol. 84 , 12226-35, (2010) 摘要
- Bosco, D.A., et al., Mutant FUS Proteins That Cause Amyotrophic Lateral Sclerosis Incorporate Into Stress Granules. Hum. Mol. Genet. 19 , 4160-75, (2010) 摘要
- Hobbs, R.P., et al., The Calcium ATPase SERCA2 Regulates Desmoplakin Dynamics And Intercellular Adhesive Strength Through Modulation Of PKCα Signaling. FASEB J. 25 , 990-1001, (2011) 摘要
- Ganley, I. G. et al., Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest Mol. Cell. 42 , 731-743, (2011) 摘要
- Merck 14 ,9272
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P342+P311
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R42 May cause sensitisation by inhalation 吸入会产生过敏反应
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