Benomyl 苯菌灵

CAS 17804-35-2 MFCD00084636

化学结构图

17804-35-2
SMILES: CCCCNC(=O)N1C(NC(=O)OC)=NC2C=CC=CC1=2

化学属性

Mol. FormulaC14H18N4O3
Mol. Weight290.32
Melting Point>;300 °C(lit.)
Solubility<0.1 G/100 ML AT 20 ºC

别名和识别编码

Chemical NameBenomyl
Synonym BC 6597 1-正丁氨基甲酰-2-苯并咪唑氨基甲酸甲酯 BBC 1-(Butylcarbamoyl)-2-benzimidazolecarbamic acid methyl ester 1-(N-Butylcarbamoyl)-2-(methoxy-carboxamido)-benzimidazol Benomyl-Imex Carbamic acid, (1-((butylamino)carbonyl)-1H-benzimidazol-2-yl)-, methyl Agrocit Benlate 1-(Butylcarbamoyl)-2-benzimidazolecarbamic acid, methyl ester Benomyl 1-正丁氨基甲酰-2-苯并咪唑氨基甲酸甲酯 NSC 263489 苯菌灵 NSC 263489 苯菌灵 苯菌灵 1-(Butylcarbamoyl)-2-benzimidazol-methylcarbamat Benomyl 50W Benlate 50 Benlate 50 W
CAS Number17804-35-2
PubChem Substance ID24863827
EC Number241-775-7
Beilstein Registry Number825455
MDL NumberMFCD00084636
Chemical Name Translation苯菌灵
Wiswesser Line NotationT56 BN DNJ BVM4 CMVO1
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分类

  • 600 Series Wastewater Methods, Acaricides, Alphabetic, Analytical Standards, Analytical/Chromatography, B, BA - BH, Benzimidazoles,
  • {SNA} A-B, Analytical Standards, Benzimidazoles, Carbamates, Food and Cosmetic Component Standards, Fungicides, Nematicides, Pesticides, Bactericides, Fungicides and Disinfectants, Standards for Personal Care and Cosmetic Products, neats, prohibited substances (EU-REGULATION No 1223/2009), 农残和代谢标准品, 分析/色谱, 按照字母排序
  • {SNA} Benzimidazoles, Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks

相关文献及参考

  • Merck 14 ,1044
  • FT-IR 2 (3), 3634:B / Structure Index 1 , 386:D:7

安全信息

GHS Symbol
WGK Germany3
Hazard Codes T,N T;N
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H340 May cause genetic defects 可能导致遗传性缺陷
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSDD6475000
Precautionary statements
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P308+P313
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
Risk Statements
  • R46 May cause inheritable genetic damage 可能引起遗传基因损害
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R50/53
  • R60 May impair fertility 可能降低生殖能力
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
UN Number 3077
Warnings 危化品目录(2015)
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,59,1991

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,59,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   21,315,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 41(8),82,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF E

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 250 ppb
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 226,771,1970

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,177,1974

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 310,143,1994

{haz

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,177,1974

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 50 ppm
REFERENCE :
   RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione
   Umana.  Review of

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 123 ppm
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 407,186,1983

TYPE OF TEST            : DNA repair
TEST SYSTEM

{hazard

TYPE OF TEST            : TDLo - Lowest publ

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2200 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   62,44,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1100 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   62,44,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 500 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology.
   (Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia)  V.1-
   1957-  Volume(issue)/page/year: 24,295,1980

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