Erythromycin Ethylsuccinate 琥乙红霉素
CAS 1264-62-6 MFCD00084692
化学结构图
SMILES: CCOC(=O)CCC(=O)OC1C(OC2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)C(C)(O)C(O)C(C)C(=O)C(C)CC2(C)O)OC(C)CC1N(C)C
化学属性
| Mol. Formula | C43H75NO16 |
|---|---|
| Mol. Weight | 862 |
| Density | 1.21 |
别名和识别编码
| Chemical Name | Erythromycin Ethylsuccinate |
|---|---|
| MDL Number | MFCD00084692 |
| CAS Number | 1264-62-6 |
| PubChem Substance ID | 443953 |
| EC Number | 215-033-8 |
| Synonym | 琥乙红霉素; 红霉素琥珀酸乙酯 Erythrocin ethyl succinate Erythromycin, ethyl succinate Erythromycin, mono(ethyl succinate) Pediamycin 红霉素琥珀酸乙酯 Erythromycin ethyl succinate 琥乙红霉素 |
| Chemical Name Translation | 琥乙红霉素 |
| Wiswesser Line Notation | T-14-VO GVTJ C2 DQ D1 EQ F1 H1 JQ J1 L1 N1 KO- BT6OTJCQ DN1&1 F1& MO- FT6OTJ B1 CQ DO1 D1 |
| Beilstein Registry Number | 0077638 |
| LabNetwork Molecule ID | LN01342871 |
| InChI | InChI=1S/C43H75NO16/c1-15-29-43(11,52)36(48)24(5)33(47)22(3)20-41(9,51)38(25(6)34(26(7)39(50)57-29)59-32-21-42(10,53-14)37(49)27(8)56-32)60-40-35(28(44(12)13)19-23(4)55-40)58-31(46)18-17-30(45)54-16-2/h22-29,32,34-38,40,48-49,51-52H,15-21H2,1-14H3/t22-,23-,24+,25+,26-,27+,28+,29-,32+,34+,35-,36-,37+,38-,40+,41-,42-,43-/m1/s1 |
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分类
- {SNA} A - K
- {SNA} A - K, Antibacterial, Antibiotics A to Z, Antibiotics A-F, Chemical Structure Class,
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards,
- {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards E - F, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
- {SNA} A - K, Antibacterial, Antibiotics A to Z, Antibiotic
- {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards E - F, 分析/色谱
产品应用
- 抗生素类药，主要用于青霉素耐药的葡萄球菌的感染。
安全信息
WGK Germany2
GHS Symbol
Precautionary statements
- P342+P311
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard statements
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
RTECSWM9800000
Signal word
Danger
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes
Xn
Safety Statements
- S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
- R42/43
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4167 mg/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 9,445,1966
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 5714 ug/kg TOXIC EFFECTS : Behavioral - ataxia REFERENCE : AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 10,616,1992
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,126,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 420 mg/kg/7D-I TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Liver - other changes REFERENCE : CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911- Volume(issue)/page/year: 129,411,1983
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