Sew2871 5-(4-苯基-5-(三氟甲基)噻吩-2-基)-3-(3-(三氟甲基)苯基)-1,2,4-恶二唑

CAS 256414-75-2 MFCD00096600

化学结构图

256414-75-2
SMILES: FC(F)(F)C1SC(=CC=1C1C=CC=CC=1)C1=NC(=NO1)C1C=C(C=CC=1)C(F)(F)F

化学属性

Mol. FormulaC20H10F6N2OS
Mol. Weight440.36
Melting Point94.5-95.3 °C

别名和识别编码

Chemical NameSew2871
CAS Number256414-75-2
Synonym SEW2871 5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 1,2,4-oxadiazole
PubChem Substance ID24724607
MDL NumberMFCD00096600
Chemical Name Translation5-(4-苯基-5-(三氟甲基)噻吩-2-基)-3-(3-(三氟甲基)苯基)-1,2,4-恶二唑
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分类

  • Sulfur & Selenium Compounds
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Bioactive Small Molecule Alphabetical Index, Lipids in Cell Signaling, S, Sphingolipids, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Lipids in Cell Signaling, S, Sphingolipids

产品应用

  • Novel, selective human Sphingosine-1-phosphate subtype 1 (S1P1) receptor agonist. It is used as medicament for treating and/or preventing cardiovascular conditions in patients with Fabry disease.

相关文献及参考

  • [2]. Jo E, et al. S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. Chem Biol. 2005 Jun;12(6):703-15.
  • [3]. Dong J, et al. Oral treatment with SEW2871, a sphingosine-1-phosphate type 1 receptor agonist, ameliorates experimental colitis in interleukin-10 gene deficient mice. Clin Exp Immunol. 2014 Jul;177(1):94-101.
  • Dudek, S., et al.: J. Biol. Chem., 279, 24692
  • [1]. Park SJ, et al. Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery. Biomol Ther (Seoul). 2017 Jan 1;25(1):80-90.
  • [1]. Park SJ, et al. Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery. Biomol Ther (Seoul). 2017 Jan 1;25(1):80-90.
  • [2]. Jo E, et al. S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. Chem Biol. 2005 Jun;12(6):703-15.
  • [3]. Dong J, et al. Or

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H300 Fatal if swallowed 吞食致命
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P310
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. S - Bioactive Small Molecules
  1. Medical Research Areas
  2. GPCR & G Protein
  3. LPL Receptor  (溶血磷脂受体)

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