beta-D-GALACTOPYRANOSE β-半乳糖苷酶

CAS 9031-11-2 MFCD00130623

化学结构图

9031-11-2
SMILES: OCC1OC(O)C(O)C(O)C1O

别名和识别编码

Synonym E.C. 3.2.1.23 Hydrolact Lactase sarcotoxin IIB protein, Sarcophaga peregrina {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL NumberMFCD00130623
CAS Number9031-11-2
EC Number232-864-1
Chemical Nameβ-Galactosidase from Escherichia coliβ-Galactosidase
Chemical Name Translationβ-半乳糖苷酶
PubChem Substance ID439353
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6-/m1/s1
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分类

  • {SA} 3.2.x.x Glycosidases,
  • {SNA} 3.2.x.x Glycosidases, 3.x.x.x Hydrolases, Apoptosis and Cell Cycle, Application Index, Carbohydrate Hydrolysis, Carbohydrate and PTM Analysis, Carbohydrate hydrolysis & PTM analysis, Enzyme Class Index, Other Apoptosis Related Reagents, Other Apoptosis Related Reagents Enzymes, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • {SNA} 3.2.x.x Glycosidases, 3.x.x.x Hydrolases, Apoptosis and Cell Cycle, Application Index, Carbohydrate Hydrolysis,
  • {SNA} 3.2.x.x Glycosidases, 3.x.x.x Hydrolases, Application Index, Carbohydrate Hydrolysis, Carbohydrate and PTM Analysis,

产品应用

  • β-Galactosidase is conjugated to an antibody that specifically recognizes a target molecule (enzyme immunoassay or EIA). β-Galactosidase is also used as a reporter enzyme to monitor the level of gene expression of a promoter.

相关文献及参考

  • 1. D.H. Juers et al., Structural comparisons of TIM barrel proteins suggest functional and evolutionary relationships between &#946-galactosidase and other glycohydrolases Protein Sci. 8 , 122-139, (1999)
  • Fowler, A.V., et al., Amino acid sequence of beta-galactosidase XI; Peptide ordering procedures and the complete sequence. J. Biol. Chem. 253 , 5521, (1978)

安全信息

WGK Germany3
RTECSLW5840000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 4 储存温度-20°C 储存温度2-8℃
GHS Symbol
Safety Statements
Precautionary statements
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P304+P340
  • P342+P316
  • P403 Store in a well-ventilated place. 储存在通风良好的地方。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4090 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 4,725,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1470 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 4,729,1970

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 4,725,1970

{hazard_co

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 630 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 4,729,1970

Hazard statements
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难

其他信息

  • β-Galactosidase has a molecular weight of 540 kDa, and an optimum pH range of 6 to 8. Product G128643 is not suitable for immunoconjugation applications due to the presence of ammonium sulfate.
  • 无臭，微甜。分子量100000～850000。在水中呈混沌液(大部分溶解)，不溶于乙醇、丙酮。不同来源的酶最适pH值在4.0～7.5不等。最适作用温度37～50℃，低温保存。可由米曲霉(Aspergillus oryzae)培养液或制干酪时所得的乳清制得。作药物，适用于婴儿各种乳糖消化不良症及腹泻等。

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Analytical Enzymes - Enzymes, Inhibitors, and Substrates
  5. Novozymes: Quality Environmentally-Friendly Enzymes - Analytical Enzymes
  1. Life Science 生命科学
  2. Proteomics 蛋白质组学
  3. Protein Electrophoresis - Proteomics
  4. Molecular Weight Markers - Protein Electrophoresis
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Class Index - Enzymes, Inhibitors, and Substrates
  5. 3.x.x.x Hydrolases - Enzyme Class Index
  6. 3.2.x.x Glycosidases - 3.x.x.x Hydrolases
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Carbohydrate hydrolysis & PTM analysis - Application Index
  6. Carbohydrate and PTM Analysis - Carbohydrate hydrolysis & PTM analysis
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Organic Synthesis and Immobilized Enzymes - Application Index
  6. Organic Synthesis - Organic Synthesis and Immobilized Enzymes
  1. Releasing Factors - Peptides for Cell Biology
  2. GH-RH - Releasing Factors

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