Phleomycin 腐草霉素
CAS 11006-33-0 MFCD00131846
化学结构图
SMILES: C[C@@]1(O[C@@H]2O[C@@H](CO)[C@H](O)[C@@](O)([C@H]2O)C(N)=O)[C@H](O[C@@H]([C@H](NC(=O)c2[n]c([n]c(N)c2C)[C@@H](CC(N)=O)NC[C@H](N)C(N)=O)C(=O)N[C@H](C)[C@H](O)[C@H](C)C(=O)N[C@@H](C(=O)NCCC2=N[C@H](CS2)c2[n]c(c[s]2)C(N)=O)C(C)=O)c2c[nH]c[n]2)O[C@@H](CO)[C@@H](O)[C@@H]1O
化学属性
| Mol. Weight | 1 |
|---|---|
| Mol. Formula | H2 |
别名和识别编码
| MDL Number | MFCD00131846 |
|---|---|
| Chemical Name | Phleomycin |
| Synonym | NSC 616586 Phleomycin complex Phleomycin from Streptomyces verticillus |
| InChIKey | QRBLKGHRWFGINE-UGWAGOLRSA-N |
| Chemical Name Translation | 腐草霉素 |
| CAS Number | 11006-33-0 |
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分类
- {SA} Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antibiotics for Scale-Up Cell Culture, Antifungal, Antineoplastic and Immunosuppressive Antibiotics, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Culture Supplies, Cell Signaling and Neuroscience, Chemical Structure Class, Core Bioreagents, DNA Synthesis Inhibitors, DNA metabolism, Genetic Marker Selection, Glycopeptides, Interferes with DNA Synthesis, Labware, Life Science Reagents for Cell Culture, Mechanism of Action, P, Research Essentials,
- {SNA} Antibiotics,
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 19,260,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 13 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 19,260,1966
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 13 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 19,260,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : TXAPA9 Toxicology and
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE
TYPE OF TEST : DNA damage TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 500 ug/L/30M REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(
TYPE OF TEST : DNA damage TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 1250 ug/L REFERENCE : BICHAW Biochemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1962- Volume(issue)/page/year: 13,307,1974
TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : 1 ug/disc REFERENCE : AEMIDF Applied and Environmental Microbiology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976- Volume(issue)/page/year: 43,177,1982
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Subcutaneous TEST SYSTEM : Rodent - mouse DOSE/DURATION : 2500 ug/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 6,289,1968
TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 50 mg/L REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUE
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Human Leukocyte DOSE/DURATION : 1 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 7,251,1969
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