Urokinase 尿激酶
CAS 9039-53-6 MFCD00132566
化学结构图
SMILES:
化学属性
| TSCA | Yes |
|---|---|
| Mol. Formula | H2 |
| Mol. Weight | 1 |
别名和识别编码
| MDL Number | MFCD00132566 |
|---|---|
| CAS Number | 9039-53-6 |
| EC Number | 232-917-9 |
| Synonym | 尿激酶 E.C. 3.4.21.31 u-Plasminogen activator Urokinase plasminogen activator U-血纤维蛋白溶酶原激活剂 Urokinase 来源于人类尿液 Urokinase from human kidney cells EC 3.4.21.73 WIN-kinase WIN 22005 Urokinase Tissue culture urokinase UK TCUK E.C. 3.4.99.26 |
| Merck Number | 14,9887 |
| Chemical Name | Urokinase |
| Chemical Name Translation | 尿激酶 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- 3.4.x.x Peptidases, 3.x.x.x Hydrolases, Application Index, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Substrates, Plasma & Blood Proteins, Plasmin, Proteases, Proteases & Protein Sequencing, Proteins and Derivatives, Proteolytic Enzymes,
产品应用
- 尿激酶是一种蛋白酶,切割纤维蛋白溶酶原(plasminogen)形成纤溶酶(plasmin)。它结合到细胞表面受体（uPAR）,调节细胞粘附组织改建和迁移，同时也激活细胞内信号转导通路。尿激酶是由三部分域组成：同源于表皮生长因子（epidermal growth factor）的氨基末端域，是通过中央kringle域结合到羧基末端的蛋白酶域。
相关文献及参考
- Merck: 14,9887
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P301+P310
- H300 Fatal if swallowed 吞食致命
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2727 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,164,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2727 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,164,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >3000 ku/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 15,514,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2727 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >909 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,164,1990
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 4242 ug/kg SEX/DURATION : female 7-13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,981,1974
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 14141 ug/kg SEX/DURATION : female 7-13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,981,1974
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 1414 ug/kg SEX/DURATION : female 7-13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,981,1974
其他信息
- 为人尿或肾细胞的蛋白水解酶。天然底物是纤溶酶原。对湿敏感。溶于水。干粉在4℃较稳定，水溶液在4℃的稳定期为3天。
- Physical properties High molecular weight form migrating at 54 kDa by SDS-PAGE under non-reducing conditions
- Physical properties
- 为人尿或肾细胞的蛋白水解酶。天然底物是纤溶酶原。对湿敏感。溶于水。干粉在4℃较稳定，水溶液在4℃的稳定期为3天。 Physical form Lyophilized from 1 mL of 50 mM Tris-HCl, pH 7.4 with 100 mM NaCl, 0.1% PEG 6000, and 200 mM mannitol
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