Methyl 2,5-Dihydroxycinnamate 2,5-二羟基肉桂酸甲酯

CAS 63177-57-1 MFCD00132932

化学结构图

63177-57-1
SMILES: COC(=O)/C=C/C1C=C(O)C=CC=1O

化学属性

Mol. FormulaC10H10O4
Mol. Weight194.19
TSCANo
Melting Point180.0 to 184.0 deg-C

别名和识别编码

Chemical NameMethyl 2,5-Dihydroxycinnamate
CAS Number63177-57-1
Synonym Methyl 2,5-dihydroxycinnamate 2,5-Dihydroxycinnamic acid methyl ester Erbstatin analog Methyl 2,5-dihydroxycinnamate 3-(2,5-Dihydroxyphenyl)-
MDL NumberMFCD00132932
PubChem Substance ID354334085
Chemical Name Translation2,5-二羟基肉桂酸甲酯
Reaxys-RN8140004
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分类

  • {SNA} Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Epidermal Growth Factor Receptor (EGFR), Kinase/Phosphatase Biology, P to Q, Protein Kinase Inhibitors, Protein kinase, tyrosine, EGF receptor, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • Inhibitors; Tyrosine Kinase Inhibitors
  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, DIG-DY, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Epidermal Growth Factor Receptor (EGFR), Kinase/Phosphatase Biology,

产品应用

  • A stable Erbstatin analogue that inhibits tyrosine kinase. Shown to delay the S-phase induction by epidermal growth factor in quiescent normal rat kidney cells, without affecting the total amount of

相关文献及参考

  • Zheng, J., et al.: Br. J. Pharmacol., 130, 1115 (2000),
  • Zhou, G., et al.: J. Clin. Invest., 108, 1167 (2001),
  • Haier, et al., Influence of phosphotyrosine kinase inhibitors on adhesive properties of highly and poorly metastatic HT-29 colon carcinoma cells to collagen. Int. J. Colorectal Dis. 14 , 119-127, (1999) 摘要
  • Basson, et al., Effects of modulation of tyrosine phosphorylation on brush border enzyme activity in human Caco-2 intestinal epithelial cells. Cell Tissue Res. 292 , 553-562, (1998) 摘要
  • Geltz, et al., The p85 and p110 subunits of phosphatidylinositol 3-kinase-alpha are substrates, in vitro, for a constitutively associated protein tyrosine kinase in platelets. Blood 91 , 930-939, (1998) 摘要

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P312+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
Signal word Danger Warning
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H331 Toxic if inhaled 吸入中毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes T Xn
WGK Germany3
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S22 Do not breathe dust 不要吸入粉尘;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R22 Harmful if swallowed 吞咽有害

系列性分类


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