1-Ethyl-6-Fluoro-4-Oxo-7-(Piperazin-1-Yl)-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid 1-乙基-6-氟-1,4-二氢-4-氧代-7-(-哌嗪基)-1,8-萘啶-3-羧酸

CAS 74011-58-8 MFCD00133308

化学结构图

74011-58-8
SMILES: CCN1C=C(C(O)=O)C(=O)C2C=C(F)C(=NC1=2)N1CCNCC1

化学属性

Mol. FormulaC15H17FN4O3
Mol. Weight320.36
Melting Point220-224

别名和识别编码

Chemical Name1-Ethyl-6-Fluoro-4-Oxo-7-(Piperazin-1-Yl)-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid
CAS Number74011-58-8
Synonym Flumark Enofloxacin 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic Acid CI 919 Bactidan Enoksetin Comprecin AT-2266 PD 107779 Penetrex 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid NSC 629661 1-乙基-6-氟-1,4-二氢-4-氧代-7-(1-哌嗪基)-1,8-萘啶-3-羧酸 Enoxacin 依诺沙星 Enoram Enofloxacine
MDL Number
PubChem Substance ID87560179
InChIKeyIDYZIJYBMGIQMJ-UHFFFAOYSA-N
Chemical Name Translation1-乙基-6-氟-1,4-二氢-4-氧代-7-(-哌嗪基)-1,8-萘啶-3-羧酸
Reaxys-RN3628995
Merck Number3587
Wiswesser Line NotationT66 BV EN GNJ CVQ E2 IF H- DT6M DNTJ
Beilstein Registry Number3628995
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分类

  • A - K, ABC Transporter Research, Alphabetic, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Chemical Structure, Chemical Structure Class, Chromatography, Drugs & Metabolites, Drugs of Abuse, E, EA - EO, Enzymes, Inhibitors, and Substrates, Forensic and Veterinary Standards, Inhibitors,
  • {SNA} Alphabetical Index

产品应用

  • A flurorquinolone antibacterial used to treat urinary tract infections and gonorrhea.

相关文献及参考

  • Liu, A., et al.: Antimicrob. Agents Chemother., 54, 1393 (2010),
  • Chen, P., et al.: Drug Test Anal., 2, 24 (2010),
  • Gohil, V., et al.: Nat., Biotechnol., 28, 249 (2010),
  • Yoshida, H., et al. J. Bacteriol. 172 , 6942-6949, (1990)
  • Merck 14 ,3587

安全信息

RTECSQN2800000
WGK Germany2
GHS Symbol 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >1600 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   32(Suppl 3),192,1984

{h

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >1600 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   32(Suppl 3),192,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 327 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   32(Suppl 3),192,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
   Skin and Appendages - hair
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8

TYPE OF TEST            : LD50 - Lethal dos

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 200 ng/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 281,207,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 11 gm/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   32(Suppl 3),301,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 91 gm/kg
SEX/DURATION            : male 13 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   32(Suppl 3),293,1984

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Chemical Structure Class - Antibiotics
  4. Quinolones and Fluoroquinolones - Chemical Structure Class
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Multi-Drug Resistance and Drug Metabolism - Cell Signaling and Neuroscience
  5. Multi-Drug Resistance - Multi-Drug Resistance and Drug Metabolism
  6. ABC Transporter Research - Multi-Drug Resistance

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