C15H21Cln2O2 盐酸芬司必利

CAS 5053-08-7 MFCD00133315

化学结构图

5053-08-7
SMILES: Cl.O=C1NCC2(CCN(CCc3ccccc3)CC2)O1

化学属性

Mol. FormulaC15H20N2O2·HCl
Mol. Weight296.80

别名和识别编码

Chemical NameC15H21Cln2O2
CAS Number5053-08-7
Synonym 3612 S 3612-S 8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro(4.5)decan-2-one hydrochloride 8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one Hydrochloride 8-(2-苯乙基)-1-氧杂-3,8-二氮杂螺[4.5]癸烷-2-酮 盐酸盐 8-N-Fenetil-1-oxa-2-oxo-3,8-diazaspiro-(4,5)-decano cloridrato Chlorhydrate de phenethyl-8-oxa-1-diaza-3,8-spiro(4,5)decanone-2 Decaspir Decaspiride Decaspiride hydrochloride Erespal Espiran Fenspiride Fenspiride hydrochloride Fluiden JP 428 JP 428 hydrochloride NAT 333 NAT-333 hydrochloride NDR 5998A NDR-5998A hydrochloride Phenethyl-8-oxa-1-diaza-3,8-spiro(4,5)decanone-2-hydrochloride Pneumorel Respiride Tegencia Tegencia hydrochloride Viarespan Viarespan hydrochloride decaspiride {PubChem
MDL NumberMFCD00133315
EC Number225-752-9
PubChem Substance ID68626
Chemical Name Translation盐酸芬司必利
Wiswesser Line NotationT6N CXTJ A2R& C-& DT5MVOX EHJ &GH
LabNetwork Molecule IDLN01304216
Reaxys-RN9017699
Merck Number3999
InChIInChI=1S/C15H20N2O2.ClH/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13;/h1-5H,6-12H2,(H,16,18);1H
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites, F, FA - FL, Forensic and Veterinary Standards, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, Neat Compounds, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Additional Standards, Analytical Standards, Antiasthmatic Drug Standards, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, Neat Compounds,

产品应用

  • Bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. It also may be an antagonist a

相关文献及参考

  • [2]. Khawaja AM, Liu YC, Rogers DF. et al.Effect of fenspiride, a non-steroidal antiinflammatory agent, on neurogenic mucus secretion in ferret trachea in vitro. Pulm Pharmacol Ther. 1999;12(6):363-8.
  • [3]. Zielnik-Jurkiewicz B, Jurkiewicz D. et al. Usefulness of fenspiride in the treatment of acute otitis media in children. Pol Merkur Lekarski. 2005 Jun;18(108):624-8.
  • [4]. Bee D, Laude EA, Emery CJ, Howard P. Effect of fenspiride on pulmonary function in the rat and guinea pig. Clin Sci (Lond). 1995 Mar;88(3):325-30.
  • [5]. Fenspiride
  • .[The efficacy of application of fenspiride (erespal) for the treatment of exacerbation of bronchial asthma in children.]
  • .[The efficacy of application of fenspiride (erespal) for the treatment of exacerbation of bronchial asthma in children.]
  • LeDouarec, et al.: Arzneim.-Forsch., 19, 1263 (1969),
  • Lho, D., et al.: J. Anal. Toxicol., 14, 73 (1990),
  • Vestn Otorinolaringol. 2011;(4):66-67.

安全信息

Hazard Codes Xn
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P302+P352
  • P304+P312
  • P304+P340
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H332 Harmful if inhaled 吸入有害
Signal word Warning
RTECSRO0375000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 437 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depre

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 210 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 193,111,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 193,111,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 74 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Behavioral - aggression
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   117,343,1978

TYPE OF TEST

Storage condition 0-10°C

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs & Metabolites - Forensic and Veterinary Standards
  6. Neat Compounds - Drugs & Metabolites
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Immune Cell Signaling and Blood - Cell Signaling and Neuroscience
  5. Immune System Regulation - Immune Cell Signaling and Blood
  6. Immunomodulators and Antibiotics - Immune System Regulation
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Histamine Receptor  (组胺受体)

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