Milrinone 米利酮

CAS 78415-72-2 MFCD00133539

化学结构图

78415-72-2
SMILES: CC1NC(=O)C(=CC=1C1C=CN=CC=1)C#N

化学属性

Mol. FormulaC12H9N3O
Mol. Weight211
TSCANo
Melting Point264°
Density1.422

别名和识别编码

Chemical NameMilrinone
CAS Number78415-72-2
Synonym 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile 1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile Win 47203 Corotrope WIN 47203 Milrinone YM 018 Milrila
MDL NumberMFCD00133539
PubChem Substance ID87577949
EC Number278-903-6
Alfabeta NameMETHYLOXODIHYDROBIPYRIDINECARBONITRILEMILRINONE 2616345()---------,,'
Merck Number6197
Beilstein Registry Number3546821
Reaxys-RN3546821
Chemical Name Translation米利酮
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, M, Phosphodiesterase Inhibitors, Sanofi Aventis

产品应用

  • Selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Cardiotonic.

相关文献及参考

  • [2]. Hentschel T, et al. Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure. Anesthesiology. 2007 Jan;106(1):124-31.
  • [3]. Kishi T, et al. Effects of milrinone on left ventricular end-systolic pressure-volume relationship of rat hearts in situ. Clin Exp Pharmacol Physiol. 2001 Sep;28(9):737-42.
  • [4]. Taylor MS, et al. Effect of milrinone on small mesenteric artery vasoconstriction: role of K(+) channels. Am J Physiol. 1999 Jul;277(1 Pt 1):G69-78.
  • Alousi, A.A., et al.: J. Cardiovasc Pharmacol., 5, 792 (1983),
  • Maskin, C.S., et al.: Circulation, 67, 1065 (1983),
  • Sinoway, L.S., et al.: J. Am. Coll. Cardiol., 2, 327 (1983),
  • [1]. Santhosh KT, et al. Milrinone attenuates thr
  • [1]. Santhosh KT, et al. Milrinone attenuates thromboxane receptor-mediated hyperresponsiveness in hypoxic pulmonary arterial myocytes. Br J Pharmacol. 2011 Jul;163(6):1223-36.

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H331 Toxic if inhaled 吸入中毒
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSDW1762000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P310+P330
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Warnings IRRITANT
Safety Statements
Hazard Codes T
Risk Statements
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
Packing GroupIII
UN Number 2811 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
D

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 73 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,245,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 58 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 27,652,1996

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >25 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Cardiac - other changes
   Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Toky

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 44400 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Cardiac - cardiomyopathy including infarction
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY

Hazard Class6.1

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. M - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. Sanofi Aventis - Approved Therapeutics/Drug Candidates
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Phosphodiesterase Inhibitors - Cyclic Nucleotide Metabolism
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Phosphodiesterase Inhibitors - Cyclic Nucleotide Metabolism
  1. Medical Research Areas
  2. Metabolism
  3. Phosphodiesterase (PDE)  (磷酸二酯酶)

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