2-((3-Chloro-2-Methylphenyl)Amino)Benzoic Acid 2-((3-氯-2-甲基苯基)氨基)苯甲酸
CAS 13710-19-5 MFCD00133865
化学结构图
SMILES: CC1=C(Cl)C=CC=C1NC1C=CC=CC=1C(O)=O
化学属性
| Mol. Formula | C14H12ClNO2 |
|---|---|
| Mol. Weight | 262 |
| Melting Point | 209.0 to 214.0 deg-C |
| TSCA | No |
别名和识别编码
| Chemical Name | 2-((3-Chloro-2-Methylphenyl)Amino)Benzoic Acid |
|---|---|
| CAS Number | 13710-19-5 |
| Synonym | 2-((3-Chloro-2-methylphenyl)amino)benzoic acid N-(3-Chloro-2-methylphenyl)anthranilic acid Benzoic acid, 2-((3-chloro-2-methylphenyl)amino)- Tolfenamic acid 2-[(3-Chloro-2-methylphenyl)amino]benzoic Acid N-(3-Chloro-ortho-tolyl) anthranilic acid 2-(3-氯-2-甲基苯胺)苯甲酸 2-([3-氯-2-甲苯基]氨基)苯甲酸 N-(3-Chloro-o-tolyl)-anthranilic acid GEA 6414 2 (3-Chloro-2-methylanilino)benzoic acid N-(2-Methyl-3-chlorophenyl)anthranilic acid 托灭酸 |
| MDL Number | MFCD00133865 |
| PubChem Substance ID | 87558900 |
| EC Number | 237-264-3 |
| Merck Number | 9513 |
| Reaxys-RN | 657821 |
| Chemical Name Translation | 2-((3-氯-2-甲基苯基)氨基)苯甲酸 |
| Wiswesser Line Notation | QVR BMR CG B1 |
| Beilstein Registry Number | 0657821 |
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分类
- {SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, T, TF - TO, Tolfenamic
- {SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Additional Standards, Analytical Standards, Chromatography, Opiates / Synthetic Analgesic Drug Standards, Pharmaceutical Standards, Pharmaceuticals, Illicit Drugs & Alcohol, Tolfenamic, 分析/色谱
- {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, T, TF - TO
- {SNA} Enzyme Inh
产品应用
- Non-steroidal anti-inflammatory drugs (NSAIDs).
相关文献及参考
- Pentikaeinen, P., et al.: Eur. J. Clin. Pharmacol., 19, 359 (1981),
- Bundscherer, A., et al.: Oncol. Rep., 19, 547 (2008),
安全信息
GHS Symbol
- P301+P310+P330
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P405 Store locked up. 上锁保管。
- P301+P310
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- H301 Toxic if swallowed 吞食有毒
- R22 Harmful if swallowed 吞咽有害
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 246 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 14,838,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 185 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 14,838,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 225 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 28,99,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 562 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Da
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 648 mg/kg
SEX/DURATION : female 17-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.1- 1954- Volume(issue)/page/year: 29,889,1983TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 1 mg/kg SEX/DURATION : female 21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 27,117,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 264 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 29,889,1983
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