2-(3,4-Dihydroxybenzylidene)Malononitrile 2-(3,4-二羟基亚苄基)丙二腈

CAS 118409-57-7 MFCD00133899

化学结构图

118409-57-7
SMILES: N#CC(=CC1=CC(O)=C(O)C=C1)C#N

化学属性

Mol. FormulaC10H6N2O2
Mol. Weight186
TSCANo

别名和识别编码

Chemical Name2-(3,4-Dihydroxybenzylidene)Malononitrile
CAS Number118409-57-7
Synonym (3,4-Dihydroxybenzylidene)-malononitrile, RG-50810 (3,4-Dihydroxybenzylidene)malononitrile RG-50810 Tyrphostin 23 Tyrphostin AG-18
MDL NumberMFCD00133899
PubChem Substance ID354334883
Chemical Name Translation2-(3,4-二羟基亚苄基)丙二腈
Reaxys-RN3130787
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Epidermal Growth Factor Receptor (EGFR), Kinase/Phosphatase Biology, P to Q, Protein Kinase Inhibitors, Protein kinase, tyrosine, EGF receptor, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors, T, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • Inhibitors; Tyrosine Kinase Inhibitors
  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Epidermal Gr

产品应用

  • A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM).

相关文献及参考

  • Lyall, R. M., et al.: J. Biol. Chem., 264, 14503 (1989),

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Hazard statements
  • H371 May cause damage to organs 可能导致器官损伤
GHS Symbol
Signal word
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P308+P311
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition 0-10°C

系列性分类


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