Daphnetoxin,12-((1-oxo-5-phenyl-2,4-pentadienyl)oxy)-,(12-beta(E,E))-

CAS 34807-41-5 MFCD00135953

化学结构图

34807-41-5
SMILES: C[C@@H]1[C@@H](OC(=O)/C=C/C=C/C2C=CC=CC=2)[C@@]2(O[C@@]3(O[C@@]41[C@@H]1C=C(C)C(=O)[C@@]1(O)[C@H](O)[C@@]1(CO)O[C@H]1[C@H]4[C@H]2O3)C1C=CC=CC=1)C(C)=C

化学属性

Mol. FormulaC38H38O10
Mol. Weight654.70
TSCANo

别名和识别编码

Chemical NameMezerein
Synonym 12β-[(E,E)-5-Phenyl-2,4-pentadienoyloxy]daphnetoxin Meserein Mezerein
MDL NumberMFCD00135953
PubChem Substance ID24897019
Beilstein Registry Number1675867
CAS Number34807-41-5
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分类

  • {SNA} Bioactive Small Molecules, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, M, Protein Kinase Activators, Tumor Growth Regulation, Tumor Promotors
  • {SNA} Kinase/Phosphatase Biology, Protein Kinase Activators, Tumor Promotors, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 肿瘤生长调节

安全信息

WGK Germany3
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
RTECSHB5425500
Signal word Warning
GHS Symbol
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S22 Do not breathe dust 不要吸入粉尘；
Risk Statements
  • R38 Irritating to skin 刺激皮肤
Hazard Codes Xi 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3560 ug/kg/20W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - primary irritation (after topical exposure)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - other Enzymes
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,4791,1979

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg/20W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - primary irritation (after topical exposure)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - other Enzymes
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,4791,1979

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 340 nmol/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,4126,1983

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 340 nmol/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,4126,1983

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 100 ug/L
REFERENCE :
   FACOEB Food Additives and Contaminants.  (Taylor & Francis Inc., 242 Cherry
   St., Philadelphia, PA 19106)  V.1-    1984-  Volume(issue)/page/year:
   1,179,1984

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 16 nmol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 4,1507,1983

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 20 mg/L
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 294,263,1981

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 100 nmol/L
REFERENCE :
   CNREA8 Cancer Research

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Protein Kinase Activators - Kinase/Phosphatase Biology
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. M - Bioactive Small Molecules

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