Netropsin 纺锤霉素
CAS 1438-30-8 MFCD00144883
化学结构图
SMILES: Cn1cc(NC(=O)c2cc(NC(=O)CNC(=N)N)cn2C)cc1C(=O)NCCC(=N)N
化学属性
| Mol. Formula | C18H26N10O3 |
|---|---|
| Mol. Weight | 430.54 |
| Density | 1.52 |
| Stability | 对光敏感 |
| Melting Point | 168-172°C |
别名和识别编码
| Chemical Name | N,4'-Bi(pyrrole-2-carboxamide),N'-(2-carbamoylethyl)-4-((2-guanidinoacetimidoyl)amino)-1,1'- dimethyl- |
|---|---|
| MDL Number | MFCD00144883 |
| CAS Number | 1438-30-8 |
| Beilstein Registry Number | 0376913 |
| Synonym | 2814-A Antibiotic 1142 Antibiotic T-1384 CH-777-A Congocidin Congocidin Sinanomycin Congocidine F 6 Hydrochloride, Netropsin IA 887 IA-887 K-117 Netropsin Netropsin Hydrochloride Netropsin dihydrochloride hydrate Sinanomycin T 1384 T-1384 纺锤菌素 |
| PubChem Substance ID | 4461 |
| Chemical Name Translation | 纺锤霉素 |
| Wiswesser Line Notation | T5NJ A1 BVM2VZ EMV- BT5NJ A1 DMYUM&1MYZUM |
| InChI | InChI=1S/C18H26N10O3/c1-27-9-11(6-12(27)16(30)23-4-3-14(19)20)26-17(31)13-5-10(8-28(13)2)25-15(29)7-24-18(21)22/h5-6,8-9H,3-4,7H2,1-2H3,(H3,19,20)(H,23,30)(H,25,29)(H,26,31)(H4,21,22,24) |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, N, 抗生素, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 脱氧核糖核酸酶 I, 酶、抑制剂和底物
- {SNA} Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antiviral,
产品应用
- 含n-甲基吡咯寡肽，结合到dsDNA的富AT序列上，尤其在小的凹槽位点。这样，它保护该区域免受DNase I和内切核酸酶切割，也抑制拓扑异构酶。
- 纺锤菌素打乱细胞分裂周期，延长G期，并使分裂停止在G期。
- 医药上具有抗细菌、真菌、锥体虫、牛痘病毒、噬菌体等作用。
安全信息
GHS Symbol
- H301 Toxic if swallowed 吞食有毒
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P301+P310
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 70 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 2,1180,1978
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 9,102,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 2,1180,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 17 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 2,1180,1978
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 40 mg/L/3H REFERENCE : CRSUBM Cancer Research Supplement. (Baltimore, MD) No.1-4, 1953-56. Volume(issue)/page/year: 3,69,1955
TYPE OF TEST : DNA inhibition TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 200 mg/L REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,1144,1980
TYPE OF TEST : DNA damage TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 500 umol/L REFERENCE : MLBRBU Molecular Biology Reports. (Dr. W. Junk Pub., POB 163, 3300 AD Dordrect, Netherlands) V.1- 1973- Volume(issue)/page/year: 2,135,1975
其他信息
- 链霉菌Streptomyces netropsis产生的抗生素。溶于水(30mg/ml，80℃，＞0.5mg/ml，25℃)，不溶于一般有机溶剂。盐酸盐吸湿性强。
京ICP备2020036287号