2H-Tetrazolium, 2,2'-(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[3-(4-nitrophenyl)-5-phenyl-, chloride (1:2) 氯化硝基四氮唑兰

CAS 298-83-9 MFCD00012159

化学结构图

298-83-9
SMILES: [Cl-].[Cl-].COC1C=C(C=CC=1[N+]1=NC(=NN1C1C=CC(=CC=1)[N+]([O-])=O)C1C=CC=CC=1)C1=CC(OC)=C(C=C1)[N+]1=NC(=NN1C1C=CC(=CC=1)[N+]([O-])=O)C1C=CC=CC=1

化学属性

Mol. FormulaC40H30Cl2N10O6
Mol. Weight817.64
Density1.422
Melting Point-190 °C
SolubilitySoluble in methanol (50 g/L), water (10 mg/ml), 2-methoxyethanol (20 mg/ml), and ethanol (5 mg/ml).
Stability对热,光和空气敏感

别名和识别编码

Chemical Name2H-Tetrazolium, 2,2'-(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[3-(4-nitrophenyl)-5-phenyl-, chloride (1:2)
Synonym Nitro blue tetrazolium chloride {LY} Nitro blue tetrazolium chloride {} {LY} Nitro blue tetrazolium chloride {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {} {} {}
CAS Number298-83-9
PubChem Substance ID9281
EC Number206-067-4
Beilstein Registry Number4115923
MDL NumberMFCD00012159
Reaxys-RN3896823
Chemical Name Translation氯化硝基四氮唑兰
LabNetwork Molecule IDLN00194851
InChIInChI=1S/C40H30N10O6.2ClH/c1-55-37-25-29(13-23-35(37)47-43-39(27-9-5-3-6-10-27)41-45(47)31-15-19-33(20-16-31)49(51)52)30-14-24-36(38(26-30)56-2)48-44-40(28-11-7-4-8-12-28)42-46(48)32-17-21-34(22-18-32)50(53)54;;/h3-26H,1-2H3;2*1H/q+2;;/p-2
Canonical SMILESCOC1=CC(C2=CC=C(N3N=C(C4=CC=CC=C4)N=[N+]3C5=CC=C([N+]([O-])=O)C=C5)C(OC)=C2)=CC=C1N6N=C(C7=CC=CC=C7)N=[N+]6C8=CC=C([N+]([O-])=O)C=C8.[Cl-].[Cl-]
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分类

  • {SNA} Alkaline Phosphatase Substrates for Western Blotting, Alphabetical Listing, Colorimetric, Core Bioreagents, Detection, Detection Substrates, Enzyme Substrates, Life Science Reagents for Western Blotting, Research Essentials, Stains and Dyes, Substrates, Tablets, Western Blotting, 生化试剂, 酶、抑制剂和底物
  • {SA} Alkaline Phosphatase,
  • {SNA} Alkaline Phosphatase,
  • {SNA} Cell Biology, Hematology Stains, Hematology and Histology
  • {SNA} Hematology Stains, Hematology and Histology, 细胞生物学
  • Alkaline Phosphatase, BCIP/NBT Substrate Systems, Biochemicals and Reagents,
  • {SNA} Hematology Stains, 细胞生物学, 血液学和

产品应用

  • 脱氢酶和其它过氧化酶的底物。用于测定葡萄糖-6-磷酸脱氢酶（glucose-6-phosphate dehydrogenase）；也是凝血因子I（fibrinogen）的沉淀试剂。
  • 也是碱性磷酸酶底物之一，在碱性磷酸酶的催化下生成不溶性的蓝色产物。常用于免疫组化(IHC)、免疫细胞化学(ICC)和蛋白印迹(WB)等实验。

相关文献及参考

  • Beilstein: 26,IV,1789

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H370 Causes damage to organs 导致器官损伤
  • H318 Causes serious eye damage 严重伤害眼睛
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Hazard Codes T Xn
RTECSXF8045000
Signal word {} {} {TCI} Danger
Storage condition 2-8°C, sealed storage, away from moisture and light {LY} 2-8°C, sealed storage, away from moisture and light <0°C <;0 {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {}
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P332+P313
  • P305+P351+P338+P337+P313
  • P301+P312+P330
  • P337+P313
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P302+P350
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R68/20/21/22
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险

其他信息

  • 溶于水，溶于甲醇。
  • p-Nitroblue Tetrazolium Chloride is an NADPH-diaphorase substrate that competitively inhibits NOS (nitric oxide synthase) (IC50 = 3-4 μM). p-Nitroblue Tetrazolium Chloride is a well-known scavenger of superoxide anions and is useful as a substrate for alkaline phosphatase, often in conjunction with BCIP.

系列性分类

  1. Research Essentials 基础科研
  2. Core Bioreagents - Research Essentials
  3. Life Science Reagents for Western Blotting - Core Bioreagents
  1. Life Science 生命科学
  2. Hematology and Histology 血液学和组织学
  3. Stains and Dyes - Hematology and Histology
  4. Stains &amp; Dyes, A to Z - Stains and Dyes
  5. N - Stains &amp; Dyes, A to Z
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Azo/Diazo Compounds - Nitrogen Compounds
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Substrates - Enzymes, Inhibitors, and Substrates
  5. Detection Substrates - Enzyme Substrates
  6. Alphabetical Listing - Detection Substrates
  1. Life Science 生命科学
  2. Molecular Biology 分子生物学
  3. Nucleic Acid Detection and Hybridization - Molecular Biology
  4. Substrates, Kits and Reagents for Detection - Nucleic Acid Detection and Hybridization
  5. Colorimetric - Substrates, Kits and Reagents for Detection
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Substrates - Enzymes, Inhibitors, and Substrates
  5. Substrates by Enzyme - Enzyme Substrates
  6. Cytokinin dehydrogenase - Substrates by Enzyme
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Substrates - Enzymes, Inhibitors, and Substrates
  5. Substrates by Enzyme - Enzyme Substrates
  6. Succinic dehydrogenase - Substrates by Enzyme
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Substrates - Enzymes, Inhibitors, and Substrates
  5. Substrates by Enzyme - Enzyme Substrates
  6. Thiophene-2-carbonyl-CoA monooxygenase - Substrates by Enzyme
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Substrates - Enzymes, Inhibitors, and Substrates
  5. Detection Substrates - Enzyme Substrates
  6. Western Blotting - Detection Substrates
  7. Alkaline Phosphatase - Western Blotting
  8. Powders - Alkaline Phosphatase
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Substrates - Enzymes, Inhibitors, and Substrates
  5. Detection Substrates - Enzyme Substrates
  6. Western Blotting - Detection Substrates
  7. Alkaline Phosphatase - Western Blotting
  8. Tablets - Alkaline Phosphatase
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Tetrazolium Salts & Formazans
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Detection Substrates
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Acylase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Cyanamide hydratase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Esterase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Galactosidase, beta
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Glucose Oxidase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Histamine-N-Methyltransferase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Kallikrein
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Oxaloacetate decarboxylase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Pyrrolidonyl peptidase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Subtilisin
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Succinic dehydrogenase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Tannase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Analytical Enzymes
  5. Peroxidase Enzymes and Reagents
  6. Peroxidase Inhibitors

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