9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate 9-氨基-1,2,3,4-四氢吖啶

CAS 206658-92-6 MFCD00150067

化学结构图

206658-92-6
SMILES: O.Cl.NC1C2=CC=CC=C2N=C2CCCCC2=1

化学属性

Mol. FormulaC13
Mol. Weight253
Melting Point284-286 °C(lit.)
Stability对热敏感

别名和识别编码

Chemical NameTacrine hydrochloride hydrate
Synonym THA 盐酸盐 水合物 他克林盐酸盐 单满吖啶氨 盐酸盐 水合物 9-氨基-1,2,3,4-四氢吖啶 盐酸盐 水合物
MDL NumberMFCD00150067
PubChem Substance ID24891302
CAS Number206658-92-6
Chemical Name Translation9-氨基-1,2,3,4-四氢吖啶
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分类

  • {SNA} A to C, A-AM, Acetylcholinesterase, Bioactive Small Molecule Alphabetical Index, Cholinesterase, acetyl, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • {SNA} Acridines, Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks

相关文献及参考

  • Sussman, J., et al. Proc. Natl. Acad. Sci. U. S. A. 90 , 9031, (1993) 摘要
  • Merck 14 ,9024
  • Beil. 22 ,IV,4911
  • Aldrich MSDS 1 , 115:A / Corp MSDS 1 (1), 226:C / FT-IR 2 (3), 3924:B / FT-NMR 1 (3), 443:B / IR-Spectra (2), 1214:E / IR-Spectra (3), 1393:A / NMR-Reference 2 (2), 742:C / RegBook 1 (2), 2625:K / Structure Index 1 , 414:C:4

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P301+P310
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Signal word Danger
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H351 Suspected of causing cancer 怀疑致癌
  • H319 Causes serious eye irritation 严重刺激眼睛
Hazard Codes T Xn
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S22 Do not breathe dust 不要吸入粉尘；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
Storage condition 储存温度2-8℃

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Acridines
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. A - Alphabetic
  5. AM to AQ - A
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. A to C - Enzyme Inhibitors by Enzyme
  7. Cholinesterase, acetyl - A to C

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