Mecamylamine Hydrochloride 盐酸美加明

CAS 826-39-1 MFCD00151462

化学结构图

826-39-1
SMILES: CNC1(C)[C@H]2CC[C@H](C2)C1(C)C.Cl

化学属性

Mol. FormulaC11H22ClN
Mol. Weight203.75
Solubilityethanol: 122 mg/mL

别名和识别编码

Chemical NameMecamylamine Hydrochloride
CAS Number826-39-1
Synonym 2-(Methylamino)isocamphane hydrochloride, Inversine, N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride 2-(Methylamino)isocamphane hydrochloride Inversine N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride 2-(Methylamino)isocamphane hydrochloride; Inversine; N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride 2-NORBORNANAMINE,N,2,3,3-TETRAMETHYL-,HYDROCHLORIDE 2-[METHYLAMINO]ISOCAMPHANE HYDROCHLORIDE 3-methylaminoisocamphanehydrochloride 3-methylaminoisokamfanchlorid Bicyclo2.2.1heptan-2-amine, N,2,3,3-tetramethyl-, hydrochloride MECAMYLAMINE MECAMYLAMINE USP MECAMYLAMINE HYDROCHLORIDE MECAMYLAMINE USP MecamycamineHydrochloride Mecamylamine (hydrochloride) {Chemicalbook} N,2 {} {SNA} Mecamylamine hydrochlor
MDL NumberMFCD00151462
EC Number212-555-8
PubChem Substance ID13221
Chemical Name Translation盐酸美加明
Wiswesser Line NotationL55 ATJ CM1 C1 D1 D1 &GH
InChIInChI=1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H
Canonical SMILESCC1(C)C(NC)(C)C2CCC1C2.[H]Cl
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分类

  • {S
  • Alphabetic, Analytical Standards, Analytical/Chromatography, M, MEA - MES
  • {SNA} Antagonists, Approved Therapeutics/Drug Candidates, AstraZeneca, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cholinergics,
  • {SNA} Antagonists,
  • {SNA} Antagonists, Approved Therapeutics/Drug Candidates, AstraZeneca, Bioactive Small Molecules, Cell Signaling and Neuroscience, Cholinergics, Ion Channels, Ligand-Gated Ion Channels, M, Neuroscience, Neurotransmission, Neurotransmitters, Nicotinic Acetylcholine Receptor Modulators, 细胞生物学

产品应用

  • Nicotinic receptor antagonist; orally active ganglionic blocker. Antihypertensive.

相关文献及参考

  • Stone, C.A., et al.: J. Med. Pharm. Chem., 5, 665 (1962),
  • Papke, R.L., et al.: J. Pharmacol. Exp. Ther., 297, 646 (2001),
  • Young, J.M., et al.: Clin. Ther., 23, 532 (2001),
  • Merck 14 ,5774

安全信息

RTECSRB6900000
GHS Symbol
WGK Germany3
Precautionary statements
  • P301+P310
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Danger
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xn
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
UN Number UN 2811 6.1/PG 3 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 177 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 117,169,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
   York, NY)  V.1-3, 1964-72.  Discontinued.  Volume(issue)/page/year:
   2,300,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 155 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 117,169,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 63 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    19

Storage condition 2-8°C

其他信息

  • MOL 文件:826-39-1.mol
  • Sigma Aldrich:826-39-1(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. AstraZeneca - Approved Therapeutics/Drug Candidates
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Ligand-Gated Ion Channels - Ion Channels
  6. Nicotinic Acetylcholine Receptor Modulators - Ligand-Gated Ion Channels
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. M - Alphabetic
  5. MEA - MES - M

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